{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:12:47Z","timestamp":1789456367421,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study investigated the prognostic performance of the FIB\u20103 index, composed of aspartate aminotransferase, alanine aminotransferase, and platelet count, in patients with decompensated cirrhosis and overt hepatic encephalopathy receiving rifaximin therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between March 2017 and March 2024, 235 patients were included in this multicenter retrospective study. The discriminatory performance of the FIB\u20103 index for predicting 48\u2010month survival was compared with that of the FIB\u20104 index, aMAP score, MELD 3.0 score, and Child\u2013Pugh classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The AUROCs for the FIB\u20103 index, FIB\u20104 index, aMAP score, MELD 3.0 score, and Child\u2013Pugh classification were 0.63, 0.58, 0.57, 0.71, and 0.70, respectively. Using the FIB\u20103 index as the reference model, no statistically significant differences in AUROC were observed between the FIB\u20103 index and the other models (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.05, 0.2, 0.1, and 0.1, respectively). In the NRI analysis, the FIB\u20103 index demonstrated significantly better discriminatory performance than the FIB\u20104 index (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) but poorer discriminatory performance than Child\u2013Pugh classification (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), whereas no significant differences were observed compared with the aMAP or MELD 3.0 scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.2 and 0.1, respectively). In the IDI analysis, the FIB\u20103 index showed significantly better discriminatory performance than the FIB\u20104 index (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02) but poorer discriminatory performance than the MELD 3.0 score and Child\u2013Pugh classification (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004 and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The FIB\u20103 index showed better prognostic discrimination than the FIB\u20104 index and may serve as a simple age\u2010independent fibrosis\u2010related marker that complements established liver function\u2010based prognostic models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70269","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:48:01Z","timestamp":1789454881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of the FIB\u20103 Index in Patients With Hepatic Encephalopathy Receiving Rifaximin: A Multicenter Retrospective Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3656-285X","authenticated-orcid":false,"given":"Takeshi","family":"Hatanaka","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Gunma Saiseikai Maebashi Hospital  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-7093","authenticated-orcid":false,"given":"Satoru","family":"Kakizaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Research NHO Takasaki General Medical Center  Takasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rintaro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Gunma Saiseikai Maebashi Hospital  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kanayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Gunma Saiseikai Maebashi Hospital  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4366-1699","authenticated-orcid":false,"given":"Satoshi","family":"Takakusagi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kusunoki Hospital  Fujioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9129-8361","authenticated-orcid":false,"given":"Takashi","family":"Kosone","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kusunoki Hospital  Fujioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0663-0102","authenticated-orcid":false,"given":"Atsushi","family":"Naganuma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology NHO Takasaki General Medical Center  Takasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-2344","authenticated-orcid":false,"given":"Hiroki","family":"Tojima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8633-2983","authenticated-orcid":false,"given":"Yuichi","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5924-1170","authenticated-orcid":false,"given":"Hitoshi","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kusunoki Hospital  Fujioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4425-4331","authenticated-orcid":false,"given":"Toshio","family":"Uraoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072\u2010017\u20109812\u20103"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.09.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000081990"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907893"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12803"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27210"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010021\u201001788\u2010x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u2010230x\u201012\u20102"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastha.2022.07.012"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.57.9151"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.07.025"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.08.050"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","DOI":"10.1111\/hepr.70110","article-title":"Clinical Utility of the Amap Risk Score for Predicting the Recurrence of Hepatic Encephalopathy After Rifaximin Treatment in Patients With Liver Cirrhosis: A Retrospective Cohort Study","author":"Takakusagi S.","year":"2026","journal-title":"Hepatology Research"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.07.049"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.04.031"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.453"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14041358"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i18.2221"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14275"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.70269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hepr.70269","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.70269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:48:02Z","timestamp":1789454882000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.70269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":21,"alternative-id":["10.1111\/hepr.70269"],"URL":"https:\/\/doi.org\/10.1111\/hepr.70269","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]},"assertion":[{"value":"2026-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"hepr.70269"}}