{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:14:21Z","timestamp":1747185261618,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Stroke SA"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Expectations"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Stem cell research holds the potential for a paradigm shift in the management of diseases such as stroke. Patient and public involvement in research (PPIR) can bring a focus to issues of clinical relevance and accelerate translation to real\u2010world clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>A qualitative thematic analysis of the perspectives of stroke survivors regarding the conduct and design aspects of a proposed phase I clinical cell therapy study in stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Twelve stroke survivors were purposively recruited in July 2016\u2013August 2017 and participated in semi\u2010structured, face\u2010to\u2010face interviews for input into the design of a proposed phase I clinical study of autologous dental pulp stem cells. Concurrent thematic analysis was conducted until data saturation was achieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and conclusions<\/jats:title><jats:p>Participants conveyed that the most relevant outcomes to them were regaining participation, decreased dependence on caregivers and improvement in cognition, memory, mood, pain and fatigue. The perception of risk vs. benefit was likely influenced by the time elapsed since stroke, with participants being more willing to accept a higher level of risk early in the post\u2010stroke disease course. They believed that all stroke survivors should be given an opportunity to participate in research, irrespective of their cognitive capacity. A relatively small sample population of 12 stroke survivors was studied as thematic saturation was achieved. PERSPECTIVES study applied principles of PPIR to early\u2010phase cell research. Incorporation of outcomes relevant to patients' need within the study design is critical to generate data that will enable personalized application of regenerative medicine in stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hex.12932","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T07:49:04Z","timestamp":1563868144000},"page":"1069-1077","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["PERSPECTIVES: Stroke survivors' views on the design of an early\u2010phase cell therapy trial for patients with chronic ischaemic stroke"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2711-445X","authenticated-orcid":false,"given":"Anjali","family":"Nagpal","sequence":"first","affiliation":[{"name":"Stroke Research Programme, Adelaide Medical School, The University of Adelaide South Australian Health &amp; Medical Research Institute (SAHMRI) Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Hillier","sequence":"additional","affiliation":[{"name":"Sansom Institute for Health Research University of South Australia Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin G.","family":"Milton","sequence":"additional","affiliation":[{"name":"Stroke Research Programme, Departments of Neurology and Medicine The Queen Elizabeth Hospital, &amp; Royal Adelaide Hospital, Central Adelaide Local Health Network (CALHN) Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica A.","family":"Hamilton\u2010Bruce","sequence":"additional","affiliation":[{"name":"Stroke Research Programme, Adelaide Medical School, The University of Adelaide South Australian Health &amp; Medical Research Institute (SAHMRI) Adelaide SA Australia"},{"name":"Stroke Research Programme, Departments of Neurology and Medicine The Queen Elizabeth Hospital, &amp; Royal Adelaide Hospital, Central Adelaide Local Health Network (CALHN) Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon A.","family":"Koblar","sequence":"additional","affiliation":[{"name":"Stroke Research Programme, Adelaide Medical School, The University of Adelaide South Australian Health &amp; Medical Research Institute (SAHMRI) Adelaide SA Australia"},{"name":"Stroke Research Programme, Departments of Neurology and Medicine The Queen Elizabeth Hospital, &amp; Royal Adelaide Hospital, Central Adelaide Local Health Network (CALHN) Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61953-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0643-x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.000731"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.186"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.2042"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-005234"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-004943"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000204053.36966.80"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/09593985.2014.982234"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3310\/hsdr03390"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.6-5-435"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016641111"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"e_1_2_11_15_1","unstructured":"Food and Drug Administration Considerations for the Design of Early\u2010Phase Clinical Trials of Cellular and Gene Therapy Products U.S. Department of Health and Human Services.2015.http:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/GuidanceComplianceRegulatoryInformation\/Guidances\/CellularandGeneTherapy\/UCM359073.pdf: accessed 12th January 2016."},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/09638288.2014.1001525"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-15-4"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.9.1721"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968314562115"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016728"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-014-0573-6"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002433"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.008547"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-S4-S3"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010898"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/hex.12632"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60325-5"},{"issue":"1","key":"e_1_2_11_28_1","first-page":"31","article-title":"Brain repair: Cell therapy in stroke","volume":"7","author":"Kalladka D","year":"2014","journal-title":"Stem Cells Cloning"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2011.00065"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2016.0343"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638280600648215"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128817"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/09638288.2015.1103788"},{"volume-title":"How many qualitative interviews is enough?: Expert voices and early career reflections on sampling and cases in qualitative research","year":"2012","author":"Baker SE","key":"e_1_2_11_34_1"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/1525822X05279903"}],"container-title":["Health Expectations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhex.12932","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hex.12932","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hex.12932","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hex.12932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T01:45:45Z","timestamp":1694223945000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hex.12932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,23]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/hex.12932"],"URL":"https:\/\/doi.org\/10.1111\/hex.12932","archive":["Portico"],"relation":{},"ISSN":["1369-6513","1369-7625"],"issn-type":[{"type":"print","value":"1369-6513"},{"type":"electronic","value":"1369-7625"}],"subject":[],"published":{"date-parts":[[2019,7,23]]},"assertion":[{"value":"2019-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}