{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:17:36Z","timestamp":1787170656271,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012068","name":"Health and Care Research Wales","doi-asserted-by":"publisher","award":["HF\u201017\u20101411"],"award-info":[{"award-number":["HF\u201017\u20101411"]}],"id":[{"id":"10.13039\/100012068","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Expectations"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>HIV pre\u2010exposure prophylaxis (PrEP) involves the use of antiretroviral medication in HIV\u2010negative individuals considered to be at risk of acquiring HIV. It has been shown to prevent HIV and has been available in Wales since July 2017. Measuring and understanding adherence to PrEP is complex as it relies on the simultaneous understanding of both PrEP use and sexual activity. We aimed to understand the experiences of men who have sex with men (MSM) living in Wales initiating, implementing and persisting with HIV PrEP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted semistructured interviews with MSM PrEP users in Wales who participated in a cohort study of PrEP use and sexual behaviour. Following completion of the cohort study, participants were invited to take part in a semistructured interview about their experiences of taking PrEP. We aimed to include both individuals who had persisted with and discontinued PrEP during the study. The interview topic guide was informed by the ABC taxonomy for medication adherence and the theory of planned behaviour. We analysed our data using reflexive thematic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010one participants were interviewed, five having discontinued PrEP during the cohort study. The developed themes focused on triggers for initiating PrEP, habitual behaviour, drivers for discontinuation and engagement with sexual health services. Stigma surrounding both PrEP and HIV permeated most topics, acting as a driver for initiating PrEP, an opportunity to reduce discrimination against people living with HIV, but also a concern around the perception of PrEP users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first study to investigate PrEP\u2010taking experiences incorporating established medication adherence taxonomy. We highlight key experiences regarding the initiation, implementation and persistence with PrEP and describe how taking PrEP may promote positive engagement with sexual health services. These findings may be useful for informing PrEP rollout programmes and need to be explored in other key populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient and Public Contribution<\/jats:title>\n                    <jats:p>PrEP users, in addition to PrEP providers and representatives of HIV advocacy and policy, were involved in developing the topic guide for this study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hex.13446","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T01:39:12Z","timestamp":1649986752000},"page":"1332-1341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Experiences of men who have sex with men when initiating, implementing and persisting with HIV pre\u2010exposure prophylaxis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6934-2928","authenticated-orcid":false,"given":"David","family":"Gillespie","sequence":"first","affiliation":[{"name":"School of Medicine, Centre for Trials Research, College of Biomedical &amp; Life Sciences Cardiff University Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7397-4074","authenticated-orcid":false,"given":"Fiona","family":"Wood","sequence":"additional","affiliation":[{"name":"PRIME Centre Wales and Division of Population Medicine Cardiff University Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4825-8997","authenticated-orcid":false,"given":"Adam","family":"Williams","sequence":"additional","affiliation":[{"name":"School of Medicine, Centre for Trials Research, College of Biomedical &amp; Life Sciences Cardiff University Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6877-2785","authenticated-orcid":false,"given":"Richard","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Public Health Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3100-6803","authenticated-orcid":false,"given":"Marijn","family":"de Bruin","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8247-7459","authenticated-orcid":false,"given":"Dyfrig A.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Centre for Health Economics and Medicines Evaluation, Bangor University Bangor Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0681-8108","authenticated-orcid":false,"given":"Adam T.","family":"Jones","sequence":"additional","affiliation":[{"name":"Policy, Research and International Development, Public Health Wales Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zo\u00eb","family":"Couzens","sequence":"additional","affiliation":[{"name":"Public Health Wales NHS Trust Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5268-8631","authenticated-orcid":false,"given":"Kerenza","family":"Hood","sequence":"additional","affiliation":[{"name":"School of Medicine, Centre for Trials Research, College of Biomedical &amp; Life Sciences Cardiff University Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization. HIV\/AIDS: pre\u2010exposure prophylaxis. 2021. Accessed January 26 2022.https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hiv-aids"},{"key":"e_1_2_11_3_1","unstructured":"Public Health England. HIV: annual data tables.2020. Accessed August 3 2021.https:\/\/www.gov.uk\/government\/statistics\/hiv-annual-data-tables#history"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.7954"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(21)00104-1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011205"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61127-7"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00056-2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2018-053561"},{"key":"e_1_2_11_10_1","unstructured":"BHIVA\/BASHH. BHIVA\/BASHH guidelines on the use of HIV pre\u2010exposure prophylaxis (PrEP). 2018. Accessed July 5 2021.https:\/\/www.bhiva.org\/PrEP-guidelines"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70847-3"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000220"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04167.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(16)30206-5"},{"key":"e_1_2_11_15_1","unstructured":"NHS Wales. Health in Wales. Accessed July 29 2021.https:\/\/www.wales.nhs.uk\/"},{"key":"e_1_2_11_16_1","unstructured":"GillespieD. DO\u2010PrEP webpage.2018. Accessed February 4 2021.https:\/\/www.cardiff.ac.uk\/centre-for-trials-research\/research\/studies-and-trials\/view\/do-prep"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049732315617444"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0749-5978(91)90020-T"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/2159676X.2019.1628806"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2929.2006.02467.x"},{"key":"e_1_2_11_22_1","unstructured":"QSR International Pty Ltd.NVivo.2018.https:\/\/www.qsrinternational.com\/nvivo-qualitative-data-analysis-software\/home"},{"key":"e_1_2_11_23_1","unstructured":"Communicable Disease Surveillance Centre (CDSC).Pre\u2010Exposure Prophylaxis for HIV Provision in Wales (Interim Report);2021."},{"key":"e_1_2_11_24_1","doi-asserted-by":"crossref","unstructured":"WoodFDoing qualitative health services research remotely: a rejoinder to \u2018Collecting qualitative data during a pandemic\u2019 by David Silverman. Forthcoming 2021.","DOI":"10.1558\/cam.19749"},{"issue":"48","key":"e_1_2_11_25_1","first-page":"1","article-title":"Current experiences of accessing and using HIV pre\u2010exposure prophylaxis (PrEP) in the United Kingdom: a cross\u2010sectional online survey, May to July 2019","volume":"24","author":"O'halloran C","year":"2019","journal-title":"Euro Surveill"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2020.1778628"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462419879618"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002792"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp12X659466"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25389"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2018.0106"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12132"},{"issue":"11","key":"e_1_2_11_33_1","first-page":"CD000011","article-title":"Interventions for enhancing medication adherence","volume":"2014","author":"Nieuwlaat R","year":"2014","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Health Expectations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hex.13446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hex.13446","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hex.13446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T08:11:01Z","timestamp":1692691861000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hex.13446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,14]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/hex.13446"],"URL":"https:\/\/doi.org\/10.1111\/hex.13446","archive":["Portico"],"relation":{},"ISSN":["1369-6513","1369-7625"],"issn-type":[{"value":"1369-6513","type":"print"},{"value":"1369-7625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,14]]},"assertion":[{"value":"2021-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}