{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T04:47:53Z","timestamp":1793681273683,"version":"4.5.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012921","name":"Royal College of Surgeons in Ireland","doi-asserted-by":"publisher","award":["Clement Archer Scholarship"],"award-info":[{"award-number":["Clement Archer Scholarship"]}],"id":[{"id":"10.13039\/100012921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Expectations"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Long\u2010term benzodiazepine receptor agonist (BZRA) use persists in healthcare settings worldwide and poses risks of patient harm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to develop an intervention to support discontinuation of long\u2010term BZRA use among willing individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The intervention development process aligned with the UK Medical Research Council's complex intervention framework. This involved a previous systematic review of brief interventions targeting long\u2010term BZRA use in primary care and qualitative interviews based on the Theoretical Domains Framework that explored barriers and facilitators to discontinuing long\u2010term BZRA use. A codesign approach was used involving an active partnership between experts by experience, researchers and clinicians. Intervention content was specified in terms of behaviour change techniques (BCTs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SAFEGUARDING\u2010BZRAs (Supporting sAFE and GradUAl ReDuctIon of loNG\u2010term BenZodiazepine Receptor Agonist uSe) toolkit comprises 24 BCTs and includes recommendations targeted at primary care\u2010based clinicians for operationalizing each BCT to support individuals with BZRA discontinuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The SAFEGUARDING\u2010BZRAs toolkit has been developed using a systematic and theory\u2010based approach that addresses identified limitations of previous research. Further research is needed to assess its usability and acceptability by service users and clinicians, as well as its potential to effectively support safe and gradual reduction of long\u2010term BZRA use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient or Public Contribution<\/jats:title><jats:p>The qualitative interview phase included patients as participants. The codesign process included \u2018experts by experience\u2019 with either current or previous experience of long\u2010term BZRA use as collaborators.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hex.13547","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T04:53:55Z","timestamp":1654664035000},"page":"1904-1918","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Supporting safe and gradual reduction of long\u2010term benzodiazepine receptor agonist use: Development of the SAFEGUARDING\u2010BZRAs toolkit using a codesign approach"],"prefix":"10.1111","volume":"25","author":[{"given":"Tom","family":"Lynch","sequence":"first","affiliation":[{"name":"School of Pharmacy and Biomolecular Sciences Royal College of Surgeons in Ireland Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crist\u00edn","family":"Ryan","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Bradley","sequence":"additional","affiliation":[{"name":"Department of General Practice University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Foster","sequence":"additional","affiliation":[{"name":"Benzodiazepine Action Work Group Colorado Consortium for Prescription Drug Abuse Prevention Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy","family":"Huff","sequence":"additional","affiliation":[{"name":"Benzodiazepine Information Coalition Midvale Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Lamberson","sequence":"additional","affiliation":[{"name":"Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Lynch","sequence":"additional","affiliation":[{"name":"Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathal","family":"Cadogan","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.280.6218.910"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13666"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4123"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20130076"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13570"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3951"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2015.09.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-018-0544-4"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-017-0207-7"},{"key":"e_1_2_10_11_1","first-page":"CD009652","article-title":"Psychosocial interventions for benzodiazepine harmful use, abuse or dependence","volume":"5","author":"Darker CD","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_12_1","first-page":"CD011481","article-title":"Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users","volume":"3","author":"Baandrup L","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14981"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-020-03063-z"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-10-321"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2012.09.010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hex.13392"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/qshc.2004.011155"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-5908-7-37"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-017-0605-9"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-0597.2008.00341.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-013-9486-6"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-015-0349-3"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-016-1907-3"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/hsc.13199"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-019-4626-8"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-13-117"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjhp.12102"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-020-00982-4"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-5908-6-42"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-014-0121-7"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-015-0019-8"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/inm.12894"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.949"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-016-0182-z"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/inm.12894"},{"key":"e_1_2_10_37_1","first-page":"CD011481","article-title":"Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users","volume":"3","author":"Baandrup L","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-14-80"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-029954"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.2196\/30710"}],"container-title":["Health Expectations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hex.13547","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hex.13547","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hex.13547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T12:13:39Z","timestamp":1692706419000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hex.13547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,7]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/hex.13547"],"URL":"https:\/\/doi.org\/10.1111\/hex.13547","archive":["Portico"],"relation":{},"ISSN":["1369-6513","1369-7625"],"issn-type":[{"value":"1369-6513","type":"print"},{"value":"1369-7625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,7]]},"assertion":[{"value":"2022-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}