{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:46:49Z","timestamp":1787237209958,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72074123"],"award-info":[{"award-number":["72074123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72304150"],"award-info":[{"award-number":["72304150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Expectations"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The emergence of proprotein convertase subtilisin\/kexin type 9 inhibitors offered dyslipidemia patients an alternative to statins for lipid\u2010lowering treatment. Understanding patient and physician preferences for lipid\u2010lowering drugs may promote shared decision\u2010making and improve treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study utilized an online discrete choice experiment (DCE) to assess the relative importance (RI) of six attributes related to lipid\u2010lowering drugs, including frequency of administration, mode of administration, reduction of low\u2010density lipoprotein cholesterol (LDL\u2010C) level, risk of myopathy, risk of liver damage, and out\u2010of\u2010pocket monthly cost. Respondents were recruited from dyslipidemia patients and cardiovascular physicians in China. A mixed logit model and latent class analysis were employed to estimate the preference coefficient, marginal willingness to pay (mWTP), and RI of attributes. Ethical approval has been obtained for this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 708 patients and 507 physicians participated in the survey. Patients prioritized the \u2018risk of liver damage\u2019 (RI\u2009=\u200923.6%) with \u2018mode of administration\u2019 (RI\u2009=\u200919.2%) and \u2018frequency of administration\u2019 (RI\u2009=\u200918.8%) following closely. Contrarily, physicians prioritized the \u2018reduction of LDL\u2010C level\u2019 (RI\u2009=\u200933.5%), followed by \u2018risk of liver damage\u2019 (RI\u2009=\u200926.0%) and \u2018risk of myopathy\u2019 (RI\u2009=\u200916.1%). Patients placed a higher value on \u2018frequency of administration\u2019 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and \u2018mode of administration\u2019 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) compared to physicians, while physicians valued \u2018reduction of LDL\u2010C level\u2019 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and \u2018risk of myopathy\u2019 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.012) more than patients. Physicians exhibited higher mWTP than patients for all attributes except frequency and mode of administration. The LCA revealed three distinct patient classes: focus on oral administration, focus on hepatic safety and frequency and focus on hepatic safety and cost. Likewise, three physician classes were identified: frequency\u2010insensitive, efficacy\u2010focused and safety\u2010focused.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The preferences for lipid\u2010lowering drug therapy differed between patients and physicians in China. Physicians should take into account patients' preferences and provide personalized treatment when they formulate lipid\u2010lowering treatment plans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient or Public Contribution<\/jats:title>\n                    <jats:p>Patients participated in the questionnaire design process. They engaged in a focus group discussion to determine attributes and levels and also participated in a pilot survey to assess the comprehensibility of the questionnaires. Additionally, patients were involved in the DCE survey to express their preferences. The findings of patient preference for lipid\u2010lowering drug therapy will promote shared decision\u2010making and optimize the treatment regimen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hex.14043","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T01:06:12Z","timestamp":1712624772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Patient versus physician preferences for lipid\u2010lowering drug therapy: A discrete choice experiment"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7987-0217","authenticated-orcid":false,"given":"Lingli","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Regulatory Science and Pharmacoeconomics, School of Pharmacy Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Health Policy, School of Health Policy and Management Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoliu","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Nanjing City Qixia District Hospital Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Regulatory Science and Pharmacoeconomics, School of Pharmacy Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Regulatory Science and Pharmacoeconomics, School of Pharmacy Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Regulatory Science and Pharmacoeconomics, School of Pharmacy Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqing","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences and Leicester Clinical Trial Unit, College of Life Sciences University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3951-8061","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Regulatory Science and Pharmacoeconomics, School of Pharmacy Nanjing Medical University Nanjing China"},{"name":"Department of Health Policy, School of Health Policy and Management Nanjing Medical University  Nanjing China"},{"name":"Center for Global Health, School of Public Health Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx144"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.1047"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-7827-5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.27573"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0358-8"},{"key":"e_1_2_11_7_1","unstructured":"National Healthcare Security Administration. 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