{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:06:27Z","timestamp":1791331587146,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T00:00:00Z","timestamp":1358812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> Multidrug resistance (MDR) in B\u2010cell lymphomas still constitutes a major obstacle to the effectiveness of chemotherapy even in the anti\u2010CD20 antibody therapy era. The aim of this study was to investigate the expression of MDR\u2010associated molecules in reactive lymphadenopathy (RL), follicular lymphoma (FL), and diffuse large B\u2010cell lymphoma (DLBCL).<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> The expression of mRNA for ABC\u2010transporter family genes was determined by real\u2010time RT\u2010PCR in lymph nodes from RL, FL, and DLBCL cases. <jats:italic>MDR1<\/jats:italic> exhibited significantly stronger expression in RL, FL, and DLBCL than Raji B\u2010cell lymphoma cells. RL and FL showed significantly higher expression than DLBCL. Immunohistochemically, MDR1 positive cells were localized in the germinal centers of RL and center of the nodular lesions of FL showing associations with CD21 positive follicular dendritic cells (FDCs). Raji cells were co\u2010cultured with FDC sarcoma\u2010derived cells and the expression of <jats:italic>MDR1<\/jats:italic> and drug resistance were analyzed. The co\u2010culture of Raji cells with FDCs induced strong expression of <jats:italic>MDR1<\/jats:italic> and introduced resistance to doxorubicin\u2010induced apoptosis.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These results suggest that FDCs induce <jats:italic>MDR1<\/jats:italic> expression in reactive as well as neoplastic B\u2010cells. Inhibition of the interaction of FDCs with B\u2010cells may provide a novel strategy for treating the chemotherapy resistant fraction.<\/jats:p>","DOI":"10.1111\/his.12035","type":"journal-article","created":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T17:00:38Z","timestamp":1358874038000},"page":"414-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Expression of <i>multidrug resistance 1<\/i> gene in B\u2010cell lymphomas: association with follicular dendritic 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