{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:45:06Z","timestamp":1792071906817,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Lipid droplets (\n                      <jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>\n                      s) are dynamic storage compartments for energy\u2010rich fats that are nearly ubiquitously present in eukaryotic cells, exerting tissue\u2010specific functions in metabolically active cell types, and are increased in conditions following cellular damage or lipid overload. The\n                      <jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>\n                      \u2013cytoplasm interface is stabilized by amphiphilic proteins of the\n                      <jats:styled-content style=\"fixed-case\">PAT<\/jats:styled-content>\n                      \/perilipin family (perilipin\/perilipin\u20101, adipophilin\/perilipin\u20102, and\n                      <jats:styled-content style=\"fixed-case\">TIP<\/jats:styled-content>\n                      47\/perilipin\u20103). We evaluated the value of adipophilin immunohistochemistry for the diagnosis of diseases associated with\n                      <jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>\n                      accumulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      In human tissues, adipophilin\u2010positive\n                      <jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>\n                      s were especially prominent in steroidogenic cells of the adrenal gland, testis, and ovary, in hepatocytes and hepatic stellate cells, in cardiac, striated and smooth myocytes, in lactating mammary gland epithelial cells, and in plurivacuolar adipocytes. Variable amounts of adipophilin\u2010positive\n                      <jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>\n                      s were also detected almost ubiquitously in epithelial cells of the gastrointestinal tract and skin. In diseases associated with lipid storage, adipophilin was strongly expressed in lipid\u2010laden macrophages in atherosclerosis, in cardiomyopathies, kidney diseases, hepatocyte steatosis, colon ischaemia, and at the border of organ infarcts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Adipophilin immunohistochemistry visualizes small\n                      <jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>\n                      s in tissues under physiological and disease conditions that are not visible by conventional light microscopy. Immunohistology for adipophilin may facilitate histomorphological diagnosis of diseases and definition of the extent of metabolic dysregulation, such as in organ infarcts, cardiomyopathies, kidney diseases, and microvesicular steatosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.12038","type":"journal-article","created":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T10:41:10Z","timestamp":1349260870000},"page":"617-631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":122,"title":["Adipophilin\/perilipin\u20102 as a lipid droplet\u2010specific marker for metabolically active cells and diseases associated with metabolic dysregulation"],"prefix":"10.1111","volume":"62","author":[{"given":"Beate Katharina","family":"Straub","sequence":"first","affiliation":[{"name":"Department of General Pathology Institute of Pathology Heidelberg 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