{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:40:18Z","timestamp":1791164418584,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T00:00:00Z","timestamp":1355356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>Traditionally, it was thought that ovarian high\u2010grade serous carcinoma arises from the ovarian surface epithelium and epithelial inclusion glands and that the pathogenesis is <jats:italic>de novo<\/jats:italic>; nonetheless, a convincing precursor in the ovary or peritoneum has not been identified to date. During the last few years, however, there has been a dramatic shift in thinking, and a candidate precursor is now recognized in the fallopian tube, especially within the fimbriated end \u2013 serous tubal intra\u2010epithelial carcinoma (<jats:styled-content style=\"fixed-case\">STIC<\/jats:styled-content>). Accordingly, <jats:styled-content style=\"fixed-case\">STIC<\/jats:styled-content> is probably the earliest histologically recognizable lesion in the pathogenesis of high\u2010grade serous carcinoma, but steps in this pathway which precede <jats:styled-content style=\"fixed-case\">STIC<\/jats:styled-content> have also been proposed. With subsequent progression, <jats:styled-content style=\"fixed-case\">STIC<\/jats:styled-content> implants onto the ovary and then develops into an invasive high\u2010grade serous carcinoma with rapid tumour growth. For invasive low\u2010grade serous carcinoma, it is well\u2010established that its pathogenesis begins with serous cystadenoma\/adenofibroma, which develops sequentially into atypical proliferative serous tumour (typical serous borderline tumour), non\u2010invasive micropapillary (low\u2010grade) serous carcinoma (micropapillary serous borderline tumour) and then invasive low\u2010grade serous carcinoma in a relatively slow stepwise process. It is presumed that cystadenoma\/adenofibroma arises from epithelial inclusion glands in the ovary, but recent evidence suggests that epithelial inclusion glands originate in the fallopian tube. Alternatively, it has been proposed that the other early precursors in the low\u2010grade pathway, including serous borderline tumours, non\u2010invasive implants and endosalpingiosis, may also arise directly from tubal mucosa. Therefore, the precursor of most ovarian high\u2010grade serous carcinomas originates in the fallopian tube, and that for low\u2010grade serous tumours may also be derived from the tube. This review paper provides an overview of the fallopian tube's potential role in the pathogenesis of both types of serous neoplasms of the ovary.<\/jats:p>","DOI":"10.1111\/his.12046","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T17:48:51Z","timestamp":1350064131000},"page":"44-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":242,"title":["Fallopian tube precursors of ovarian low\u2010 and high\u2010grade serous neoplasms"],"prefix":"10.1111","volume":"62","author":[{"given":"Russell","family":"Vang","sequence":"first","affiliation":[{"name":"Department of Pathology (Division of Gynecologic Pathology) The Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Department of Gynecology and Obstetrics The Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ie\u2010Ming","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Pathology (Division of Gynecologic Pathology) The Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Department of Gynecology and Obstetrics The Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Department of Oncology The Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Kurman","sequence":"additional","affiliation":[{"name":"Department of Pathology (Division of Gynecologic Pathology) The Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Department of Gynecology and Obstetrics The Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Department of Oncology The Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.03.003"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs345"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pgp.0000179614.47838.82"},{"key":"e_1_2_5_5_1","article-title":"Clinically occult tubal and ovarian high\u2010grade serous carcinomas presenting in uterine samples: diagnostic pitfalls and clues to improve recognition of tumor origin","author":"Bagby C","journal-title":"Int. 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