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The aim of this review is to provide a practical approach to the selection and interpretation of these markers, emphasizing an understanding of their sensitivity and specificity in the particular differential diagnosis in question. The main markers discussed include those for malignant germ cell differentiation (<jats:styled-content style=\"fixed-case\">SALL<\/jats:styled-content>4 and placental alkaline phosphatase), dysgerminoma (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>4, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>117, and D2\u201040), yolk sac tumour (\u03b1\u2010fetoprotein and glypican\u20103), embryonal carcinoma (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>4, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30, and <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>2), sex cord\u2013stromal differentiation (calretinin, inhibin, <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">FOXL<\/jats:styled-content>2) and steroid cell tumours (melan\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>). In addition, the limited role of immunohistochemistry in determining the primary site of origin of an ovarian carcinoid tumour is discussed.<\/jats:p>","DOI":"10.1111\/his.12052","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T12:31:22Z","timestamp":1351168282000},"page":"71-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["A practical approach to immunohistochemical diagnosis of ovarian germ cell tumours and sex cord\u2013stromal tumours"],"prefix":"10.1111","volume":"62","author":[{"given":"Joseph T","family":"Rabban","sequence":"first","affiliation":[{"name":"Pathology Department University of California San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J","family":"Zaloudek","sequence":"additional","affiliation":[{"name":"Pathology Department University of California San Francisco San Francisco CA 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