{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:16:37Z","timestamp":1786544197827,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,5]],"date-time":"2013-02-05T00:00:00Z","timestamp":1360022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Recent studies have demonstrated that cathepsin K seems to be a powerful marker in identifying renal perivascular epithelioid cell neoplasms (<jats:styled-content style=\"fixed-case\">PEC<\/jats:styled-content>omas). However, the expression in extrarenal <jats:styled-content style=\"fixed-case\">PEC<\/jats:styled-content>omas has not been well characterized due to their rare incidence. Our aim was to investigate the expression of cathepsin K in a wide spectrum of extrar\u2010enal <jats:styled-content style=\"fixed-case\">PEC<\/jats:styled-content>omas and evaluate its potential diagnostic usefulness in comparison with other commonly used markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Twenty\u2010three cases of <jats:styled-content style=\"fixed-case\">PEC<\/jats:styled-content>oma (liver, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>9; lung, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>1; broad ligament of uterus, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>1; vertex subcutaneous soft tissue, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>1; abdominal wall, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>1; and kidney, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>10) were selected for study. All displayed a high percentage of cells with moderately to strongly positive reactions for cathepsin K (mean 91%; range 80\u2013100%). <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>45, Melan\u2010A and smooth muscle actin (<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>) were expressed in 78, 87 and 87% of cases, respectively, with various percentages of positive cells (mean, 34, 40 and 38%; range 0\u201380, 0\u201390 and 0\u201390%). Transcription factor E3 (<jats:styled-content style=\"fixed-case\">TFE<\/jats:styled-content>3) was expressed strongly in only three cases; none exhibited evidence of <jats:styled-content style=\"fixed-case\"><jats:italic>TFE3<\/jats:italic><\/jats:styled-content> gene fusion or amplification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cathepsin K appears to be more powerful than other commonly used markers in diagnosing a wide spectrum of <jats:styled-content style=\"fixed-case\">PEC<\/jats:styled-content>omas and distinguishing them from the majority of human cancers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12059","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T06:06:05Z","timestamp":1352095565000},"page":"642-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Cathepsin K expression in a wide spectrum of perivascular epithelioid cell neoplasms (<scp>PEC<\/scp>omas): a clinicopathological study emphasizing extrarenal <scp>PEC<\/scp>omas"],"prefix":"10.1111","volume":"62","author":[{"given":"Qiu","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Pathology Nanjing Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu\u2010yuan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanjing Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanjing Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanjing Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun\u2010li","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanjing Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan\u2010shan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanjing Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanjing Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru\u2010song","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanjing Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng\u2010hui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanjing Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010feng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanjing Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanjing Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010jun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanjing Jinling Hospital, Nanjing University School of Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02316.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-007-0509-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.5858\/133.4.648","article-title":"Perivascular epithelioid cell tumor","volume":"133","author":"Armah HB","year":"2009","journal-title":"Arch. 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