{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T17:48:48Z","timestamp":1773510528939,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To correlate cirrhosis histology and Laennec fibrosis scoring with portal pressure, as determined by hepatic venous pressure gradient (<jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>One hundred and four patients with biopsy\u2010proven cirrhosis and known <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> were included in the study. Semiquantitative scoring of 12 histological parameters and quantitative assessment by morphometry for septal thickness and nodule diameter and image analysis for fibrosis were performed. Laennec histological subgrading and clinical staging of cirrhosis were also performed. There were significant positive correlations between <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> and Laennec histological grade of cirrhosis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), micronodularity (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), the presence of thick fibrous septa (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.015), the amount of collagen in the space of Disse (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and the extent of fibrosis by image analysis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). Multivariate analysis, to predict high <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> (\u226516\u00a0mmHg), showed that degree of collagen in the space of Disse [<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007, odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 19.3], histological grade of cirrhosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.017, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.9) and micronodularity (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.5) independently predicted high <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Histological subclassification of cirrhosis, collagen in the space of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isse and micronodularity are independent predictors of high portal pressure. The Laennec histological subclassification of cirrhosis correlates well with clinical severity of cirrhosis, and can provide useful prognostic information.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12070","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T07:39:04Z","timestamp":1361518744000},"page":"731-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Cirrhosis histology and Laennec staging system correlate with high portal pressure"],"prefix":"10.1111","volume":"62","author":[{"given":"Archana","family":"Rastogi","sequence":"first","affiliation":[{"name":"Department of Pathology Institute of Liver and Biliary Sciences Vasant Kunj New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakhi","family":"Maiwall","sequence":"additional","affiliation":[{"name":"Department of Hepatology Institute of Liver and Biliary Sciences Vasant Kunj New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chhagan","family":"Bihari","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Liver and Biliary Sciences Vasant Kunj New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Liver and Biliary Sciences Vasant Kunj New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Hepatology Institute of Liver and Biliary Sciences Vasant Kunj New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarandeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Research Department Institute of Liver and Biliary Sciences Vasant Kunj New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeeshan Ahmad","family":"Wani","sequence":"additional","affiliation":[{"name":"Department of Hepatology Institute of Liver and Biliary Sciences Vasant Kunj New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiv Kumar","family":"Sarin","sequence":"additional","affiliation":[{"name":"Department of Hepatology Institute of Liver and Biliary Sciences Vasant Kunj New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.31.5.395"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044456"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.024"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23478"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.07.036"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03653.x"},{"key":"e_1_2_7_8_1","first-page":"407A","article-title":"The Laennec grading system for assessment of hepatic fibrosis: validation by correlation with wedged hepatic vein pressure and clinical features","volume":"32","author":"Kutami RGN","year":"2000","journal-title":"Hepatology"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9106-x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20933"},{"key":"e_1_2_7_11_1","first-page":"36","volume-title":"Portal hypertension III. 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