{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T17:22:33Z","timestamp":1785691353606,"version":"3.56.0"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to analyse the immunophenotypic and molecular features of a large series of follicular lymphomas, focusing in particular on atypical cases that fail to express <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10 and\/or bcl\u20102. Such cases present diagnostic pitfalls, especially with regard to the differential diagnosis from follicular hyperplasia and marginal zone <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell lymphoma. Therefore, we also included an immunohistochemical evaluation of stathmin, which is strongly expressed by germinal centre <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> cells, as a putative new marker for follicular lymphomas, particularly those with an atypical phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Two hundred and five follicular lymphomas were investigated with immunohistochemistry and fluorescence <jats:italic>in\u2010situ<\/jats:italic> hybridization (<jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>). The use of three distinct anti\u2010bcl\u20102 antibodies together with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10 expression data and <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content> analysis for <jats:italic>bcl\u20102<\/jats:italic> and <jats:italic>bcl\u20106<\/jats:italic> rearrangements allowed subclassification of follicular lymphoma into four distinct subgroups: (i) <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10\u2010positive\/bcl\u20102\u2010positive, (ii) <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10\u2010positive\/bcl\u20102\u2010negative, (iii) <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10\u2010negative\/bcl\u20102\u2010positive, and (iv) <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10\u2010negative\/bcl\u20102\u2010negative. All cases were bcl\u20106\u2010positive. <jats:styled-content style=\"fixed-case\">STMN<\/jats:styled-content>1 (stathmin) was shown to be helpful in diagnosing bcl\u20102\u2010negative and\/or <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10\u2010negative follicular lymphomas, and in their distinction from marginal zone <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combined immunohistological and molecular analyses reveal that follicular lymphomas showing an atypical immunophenotypic and molecular profile exist, and we demonstrate that <jats:styled-content style=\"fixed-case\">STMN<\/jats:styled-content>1 represents a novel useful diagnostic marker for these.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12076","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T09:53:38Z","timestamp":1363773218000},"page":"860-875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Another look at follicular lymphoma: immunophenotypic and molecular analyses identify distinct follicular lymphoma subgroups"],"prefix":"10.1111","volume":"62","author":[{"given":"Teresa","family":"Marafioti","sequence":"first","affiliation":[{"name":"Department of Histopathology University College Hospital London UK"},{"name":"Department of Pathology University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Copie\u2010Bergman","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pathologie Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP), Groupe Henri Mondor\u2010Albert Chenevier Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris\u2010Est Cr\u00e9teil, Facult\u00e9 de M\u00e9decine UMR\u2010S 955 Cr\u00e9teil France"},{"name":"INSERM Unit\u00e9 U955, H\u00f4pital Henri Mondor Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Calaminici","sequence":"additional","affiliation":[{"name":"Cancer Research UK Medical Oncology Unit St Bartholomew's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C","family":"Paterson","sequence":"additional","affiliation":[{"name":"Department of Histopathology University College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishvesh H","family":"Shende","sequence":"additional","affiliation":[{"name":"Department of Histopathology University College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Molecular Histopathology, Department of Pathology University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"Baia","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pathologie Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP), Groupe Henri Mondor\u2010Albert Chenevier Cr\u00e9teil France"},{"name":"INSERM Unit\u00e9 U955, H\u00f4pital Henri Mondor Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D","family":"Ramsay","sequence":"additional","affiliation":[{"name":"Department of Histopathology University College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Agostinelli","sequence":"additional","affiliation":[{"name":"Section of Haematopathology, Department of Haematology and Oncological Sciences \u2018Ser\u00e0gnoli\u2019 S. 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