{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:20:19Z","timestamp":1790180419027,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T00:00:00Z","timestamp":1361404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Biopsies from the ampulla of Vater and the common bile duct often pose diagnostic challenges. The aim of this study was to investigate the expression patterns of <jats:styled-content style=\"fixed-case\">HMGA<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">HMGA<\/jats:styled-content>2, \u03b2\u2010catenin and p53 in biopsy specimens, in order to evaluate the potential diagnostic value of these proteins in differentiating adenocarcinoma from reactive atypia or adenoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Forty\u2010eight biopsies (10 from the common bile duct and 38 from the ampulla) were selected for immunohistochemical studies; they included 14 cases of reactive atypia, 12 adenomas, and 22 adenocarcinomas. Expression of <jats:styled-content style=\"fixed-case\">HMGA<\/jats:styled-content>1 was seen in 21% of the reactive atypia cases, 42% of adenomas, and 91% of adenocarcinomas. <jats:styled-content style=\"fixed-case\">HMGA<\/jats:styled-content>2 was positive in 14% of reactive atypias, 42% of adenomas, and 86% of adenocarcinomas. The staining intensity of <jats:styled-content style=\"fixed-case\">HMGA<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">HMGA<\/jats:styled-content>2 was also significantly higher in adenocarcinomas than in adenomas or reactive atypias. Interestingly, coexpression of <jats:styled-content style=\"fixed-case\">HMGA<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">HMGA<\/jats:styled-content>2 was found in 86% of adenocarcinomas, 0% of reactive atypias, and 8% of adenomas. p53 and \u03b2\u2010catenin expression seemed not to provide additional value for discriminating adenocarcinoma from reactive atypia or adenoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HMGA<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">HMGA<\/jats:styled-content>2 might serve to discriminate between reactive atypia, adenoma and adenocarcinoma in ampulla and common bile duct biopsies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12084","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T11:10:00Z","timestamp":1357816200000},"page":"778-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Diagnostic value of <scp>HMGA<\/scp>s, p53 and \u03b2\u2010catenin in discriminating adenocarcinoma from adenoma or reactive atypia in ampulla and common bile duct biopsies"],"prefix":"10.1111","volume":"62","author":[{"given":"Vladislav","family":"Zakharov","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2010.4.2.219"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e318245e05b"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.01.014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20836"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822fbc95"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1309\/BC6DY755Q3T5W9EE"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)38926-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00689-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1137999"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4667"},{"key":"e_1_2_7_12_1","first-page":"2439","article-title":"High level expression of the HMGI (Y) gene during embryonic development","volume":"13","author":"Chiappetta G","year":"1996","journal-title":"Oncogene"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/376771a0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.08.013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1212"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2271"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601391"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-03-0151"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1460"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603654"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23560"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.140"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.139"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04121.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.125168"},{"key":"e_1_2_7_26_1","first-page":"89","article-title":"P53 expression in invasive pancreatic adenocarcinoma and precursor lesions","volume":"33","author":"Norfadzilah MY","year":"2011","journal-title":"Malays. 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