{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:39:26Z","timestamp":1791257966406,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To describe 76 cases of splenic marginal zone lymphoma (<jats:styled-content style=\"fixed-case\">SMZL<\/jats:styled-content>), including correlations with clinical and other characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Patients were predominantly female, with a median age of 62\u00a0years. The main clinical presentation was splenomegaly, except for eight cases presenting with evolution of autoimmune disorders or spontaneous splenic rupture. White pulp infiltration was nodular, with a monophasic (42%) or biphasic (53%) pattern, and associated diffuse or nodular infiltration of the red pulp, except for four cases which had atrophic white pulp. Plasmacytic differentiation and the <jats:italic><jats:styled-content style=\"fixed-case\">MYD<\/jats:styled-content>88<\/jats:italic> L265P mutation were observed in 18% and 5% of the cases, respectively. Histological progression was considered in cases with a significant association of large cells with <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i67\u00a0&gt;\u00a030% and macronodular architecture (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Other significant correlations were found between del7q (44%) and del6q (17%) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.018), <jats:styled-content style=\"fixed-case\">IGHV<\/jats:styled-content>1\u20102*04 segment usage (35%) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and unmutated <jats:italic><jats:styled-content style=\"fixed-case\">IGHV<\/jats:styled-content><\/jats:italic> (39%) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.019), and between <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5 expression (27%) and higher lymphocytosis (<jats:italic>P<\/jats:italic>\u00a0<jats:italic>=<\/jats:italic>\u00a00.002). Patients requiring intensive chemotherapy after splenectomy because of clinical and\/or histological progression had significantly shorter overall survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report the histological spectrum of <jats:styled-content style=\"fixed-case\">SMZL<\/jats:styled-content>, and discuss the differential diagnosis and requirement for molecular and cytogenetic analysis in atypical cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12092","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T10:52:48Z","timestamp":1357815168000},"page":"876-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Immunoarchitectural patterns in splenic marginal zone lymphoma: correlations with chromosomal aberrations, <i><scp>IGHV<\/scp><\/i> mutations, and survival. 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