{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:25:15Z","timestamp":1763036715745},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T00:00:00Z","timestamp":1366761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Aims<\/jats:title>Cystic lymphoid hyperplasia (CLH<\/jats:styled-content>) frequently affects the parotid gland in human immunodeficiency virus (HIV<\/jats:styled-content>)\u2010infected patients. This clinicopathological study, comprising 167 cases, aims to define the clinical\u2013pathological parameters of CLH<\/jats:styled-content> in order to elucidate the aetiopathogenesis.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>This retrospective study of 167 archival cases of CLH<\/jats:styled-content> recorded patients' age, race and gender, and the nature, site and symptoms of CLH<\/jats:styled-content>. A total of 109 cases were reviewed histologically and analyzed for HIV<\/jats:styled-content>\u20101 p24 antigen immunopositivity using standard procedures. CLH<\/jats:styled-content> of the parotid gland showed a male predominance, whereas submandibular gland (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.27) and bilateral parotid involvement favoured females (2:1). CLH<\/jats:styled-content> occurred at a younger mean age in females than males in the parotid gland (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.0035) and in the submandibular gland (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.0032). Intra\u2010lymph nodal origin was favoured, with 76.1% of cases occurring within entrapped salivary gland remnants. P<\/jats:styled-content>24 staining revealed ~90% sensitivity in HIV<\/jats:styled-content>\u2010associated CLH<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>CLH<\/jats:styled-content> should be used preferentially to describe parotid enlargement in HIV<\/jats:styled-content>\u2010infected patients. This study strongly supports the hypothesis that CLH<\/jats:styled-content> develops following ductal ectasia of entrapped salivary gland inclusions arising within lymph nodes. CLH<\/jats:styled-content> should be classified as an orofacial lesion associated strongly with HIV<\/jats:styled-content> and AIDS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12094","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T09:37:42Z","timestamp":1357810662000},"page":"1067-1074","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cystic lymphoid hyperplasia: an orofacial lesion strongly associated with HIV<\/scp> and AIDS<\/scp>"],"prefix":"10.1111","volume":"62","author":[{"given":"Shabnum","family":"Meer","sequence":"first","affiliation":[{"name":"Department of Oral Pathology Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailen","family":"Dulabh","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2000.9585"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/93.1.39"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90057-W"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198906000-00005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2003.02868.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00192436"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1998.00501.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80223-X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01605788"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000246196.35413.35"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/100.1.41"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90069-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90045-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1601-0825.2003.01006.x"},{"key":"e_1_2_7_16_1","first-page":"136","article-title":"[Cystic lymphoid hyperplasia of the parotid in relation to acquired immunodeficiency syndrome (HIV+). Apropos of 2 cases]","volume":"90","author":"Vaillant JM","year":"1989","journal-title":"Rev. Stomatol. Chir. 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