{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:49:17Z","timestamp":1779281357611,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Macrophages play a critical role in iron homeostasis by recycling iron from red cells and storing it in ferritin, an iron storage protein. The recycled iron is delivered to erythroid precursors for erythropoiesis. In this study, we aimed to determine whether ferritin is highly expressed in macrophages and erythroid precursors, and whether it can be used as a marker for these two cell types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A ferritin monoclonal antibody was developed, and immunohistochemistry was performed. In normal bone marrows, ferritin antibody stained early erythroid precursors and macrophages. In contrast, myeloid cells, lymphoid cells and megakaryocytes lacked ferritin expression. In leukaemic bone marrows, ferritin was selectively expressed in erythroid blasts (M6), whereas all other blasts were negative. In lymph nodes, ferritin was highly and specifically expressed in macrophages, whereas lymphocytes completely lacked ferritin expression. In non\u2010haematopoietic tissues, ferritin antibody highlighted alveolar macrophages in the lung, as well as sinus macrophages in the liver and spleen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We conclude that ferritin is a novel and reliable marker for macrophages and early erythroid precursors, and may be of clinical utility in the diagnosis of diseases associated with these two cell types.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12101","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T11:42:42Z","timestamp":1360582962000},"page":"931-940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Ferritin <scp>H<\/scp> is a novel marker of early erythroid precursors and macrophages"],"prefix":"10.1111","volume":"62","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology Wake Forest Baptist Health Winston Salem NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D","family":"Grier","sequence":"additional","affiliation":[{"name":"Department of Pathology Wake Forest Baptist Health Winston Salem NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Pathology Wake Forest Baptist Health Winston Salem NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Pathology Wake Forest Baptist Health Winston Salem NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangchao","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology Wake Forest Baptist Health Winston Salem NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzy V","family":"Torti","sequence":"additional","affiliation":[{"name":"Department of Molecular, Microbial and Structural Biology University of Connecticut Health Center Farmington CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank M","family":"Torti","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Connecticut Health Center Farmington CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W","family":"Beaty","sequence":"additional","affiliation":[{"name":"Department of Pathology Wake Forest Baptist Health Winston Salem NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00343-5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.24.012003.132306"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3505"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-077883"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02167.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb06379.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1983.tb02015.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0700047"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199409049629"},{"key":"e_1_2_5_11_1","first-page":"597","article-title":"Flow cytometric analysis of human bone marrow perfusion cultures: erythroid development and relationship with burst\u2010forming units\u2010erythroid","volume":"24","author":"Rogers CE","year":"1996","journal-title":"Exp. 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