{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:05:01Z","timestamp":1782252301457,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T00:00:00Z","timestamp":1369008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The incidence of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4\u2010related sialadenitis among cases of chronic sialadenitis is unknown, and so we investigated the presence of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4 plasma cells in 129 specimens from an archival collection of consecutive cases of chronic submandibular sialadenitis collected from 1969 to 1989 that had been previously extensively characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Immunohistology revealed that only three of the 129 specimens contained areas over the threshold for <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4\u2010related sialadenitis of 50 <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4 plasma cells per high\u2010power field, and these cells were part of a non\u2010specific chronic inflammatory infiltrate associated with ducts that had contained sialoliths. The infiltrate of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4 plasma cells in the series was significantly positively related to the total infiltrate of inflammatory cells, fibrosis, atrophy, lymphoid germinal centres and sialoliths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4\u2010related sialadenitis is rare and was not found in the present series. The <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4 plasma cells that were present in the glands were part of a non\u2010specific chronic inflammatory infiltrate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12122","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T18:07:35Z","timestamp":1362593255000},"page":"96-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<scp>I<\/scp>g<scp>G<\/scp>4\u2010related sialadenitis is rare: histopathological investigation of 129 cases of chronic submandibular sialadenitis"],"prefix":"10.1111","volume":"63","author":[{"given":"John D","family":"Harrison","sequence":"first","affiliation":[{"name":"Unit of Oral Pathology King's College London Dental Institute at Guy's King's College St Thomas' Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Rodriguez\u2010Justo","sequence":"additional","affiliation":[{"name":"Department of Research Pathology Faculty of Biomedical Sciences University College London Medical School University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181c811ad"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03833.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03824.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/357071"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1997.2530856.x"},{"key":"e_1_2_6_7_1","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2012"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283412fd4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2010.085613"},{"key":"e_1_2_6_10_1","first-page":"71","volume-title":"Salivary gland diseases. 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