{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T01:55:48Z","timestamp":1767664548126},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T00:00:00Z","timestamp":1371081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Histological reporting of hepatic resections of colorectal liver metastases (<jats:styled-content style=\"fixed-case\">CRLM<\/jats:styled-content>s) is limited to confirmation of diagnosis and evaluation of resection margins. More exhaustive diagnostic reporting might be warranted. Here, we critically and systematically review the potentially important histological prognostic factors in <jats:styled-content style=\"fixed-case\">CRLM<\/jats:styled-content>. Histological features such as intrahepatic spread, resection margins, and tumour response to neoadjuvant chemotherapy have been defined. Intrahepatic spread (venous, lymphatic, bile duct and perineural invasion) was evaluated in a number of studies. Meta\u2010analysis demonstrated a clear correlation between 5\u2010year overall survival and both portal vein invasion (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.8, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.3\u20132.5) and lymphatic invasion (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.7, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.4\u20132.0). The impact of hepatic vein invasion and bile duct invasion on outcome is not clear. Perineural invasion was linked to survival in one study. Resection margin is an important prognostic factor; however, the significance of the width of negative margins remains controversial. Various studies have evaluated tumour response to neoadjuvant chemotherapy, but different grading systems were used, and definite recommendations cannot be made. In conclusion, with the high incidence of <jats:styled-content style=\"fixed-case\">CRLM<\/jats:styled-content> and the increase in the number of hepatic resections, we need well\u2010defined prognostic factors, studied in homogeneous patient populations, to optimize diagnostic work\u2010up. This review identifies several of these factors.<\/jats:p>","DOI":"10.1111\/his.12124","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T00:14:04Z","timestamp":1363133644000},"page":"149-156","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Histopathological evaluation of resected colorectal cancer liver metastases: what should be done?"],"prefix":"10.1111","volume":"63","author":[{"given":"Nikki","family":"Knijn","sequence":"first","affiliation":[{"name":"Department of Pathology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannemarie A M","family":"de Ridder","sequence":"additional","affiliation":[{"name":"Department of Surgery Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis J A","family":"Punt","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Academic Medical Centre Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes H W","family":"de Wilt","sequence":"additional","affiliation":[{"name":"Department of Surgery Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris D","family":"Nagtegaal","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2356-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7032"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31811ea962"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199909000-00004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0770-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000160703.75808.7d"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318217e898"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60455-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31818a07f1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(99)00089-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1254::AID-CNCR5>3.0.CO;2-I"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh342"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9703-2"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.02.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.09.038"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316981"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318223c609"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-2114-4"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-3087"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1999.01030.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199501000-00009"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.07.007"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1997.02743.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10655"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.10188"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(99)70022-X"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2002.01382.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9594-2"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-10-27"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10422"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920701)70:1<45::AID-CNCR2820700108>3.0.CO;2-7"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000715)89:2<267::AID-CNCR10>3.0.CO;2-1"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.7471"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.5299"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2010.00170.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl386"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b0c6e4"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940601)73:11<2680::AID-CNCR2820731105>3.0.CO;2-C"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181eb2f7b"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-002-6231-x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0654-7"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12124","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.12124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:23:22Z","timestamp":1696361002000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.12124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,13]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/his.12124"],"URL":"https:\/\/doi.org\/10.1111\/his.12124","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":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