{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T14:23:16Z","timestamp":1769523796250,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T00:00:00Z","timestamp":1369008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The management of lobular <jats:italic>in situ<\/jats:italic> neoplasia (<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>) when diagnosed on core biopsy remains a controversial issue. The present study aimed to investigate the association between morphological parameters of <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> on vacuum\u2010assisted needle core biopsy (<jats:styled-content style=\"fixed-case\">VANCB<\/jats:styled-content>) and the presence of malignancy (ductal carcinoma <jats:italic>in situ<\/jats:italic>, pleomorphic lobular carcinoma <jats:italic>in situ<\/jats:italic>, or invasive carcinoma) at surgical excision (<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The study included 14 pathology departments in Italy. Available slides from 859 cases of <jats:styled-content style=\"fixed-case\">VANCB<\/jats:styled-content> reporting an original diagnosis of flat epithelial atypia, atypical ductal hyperplasia or <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>, all with subsequent surgical excision, were reviewed. Overall, 286 cases of <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>, pure or associated with other lesions, were identified, and a malignant outcome was reported at excision for 51 cases (17.8%). Among the 149 cases of pure <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>, an increased risk of malignancy emerged in women in mammographic categories R4\u2013R5 as compared with those in categories R2\u2013R3 (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.46; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.048). In the series, a statistically significant decreased malignancy risk emerged among cases without determinant microcalcifications (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that the diagnosis of pure <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">VANCB<\/jats:styled-content> warrants follow\u2010up excision, because clinicopathological parameters do not allow the prediction of which cases will present carcinoma at surgical excision.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12139","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T02:58:13Z","timestamp":1364007493000},"page":"83-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Morphological parameters of lobular <i>in situ<\/i> neoplasia in stereotactic 11\u2010gauge vacuum\u2010assisted needle core biopsy do not predict the presence of malignancy on subsequent surgical excision"],"prefix":"10.1111","volume":"63","author":[{"given":"Simonetta","family":"Bianchi","sequence":"first","affiliation":[{"name":"Division of Pathological Anatomy Department of Surgery and Translational Medicine University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetta","family":"Bendinelli","sequence":"additional","affiliation":[{"name":"Molecular and Nutritional Epidemiology Unit Cancer Research and Prevention Institute (ISPO) Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Castellano","sequence":"additional","affiliation":[{"name":"Division of Pathological Anatomy Department of Medical Sciences University of Turin Turin 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Unit AORN Cardarelli Hospital Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Licia","family":"Laurino","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Unit General Hospital of Treviso Treviso Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Bersiga","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Unit Istituti Ospitalieri di Cremona Cremona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela","family":"Giardina","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Dante","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Unit Hospital of Vicenza Vicenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Di","family":"Loreto","sequence":"additional","affiliation":[{"name":"Division of Pathological Anatomy Department of Medical and Biological Sciences University of Udine Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela","family":"Quero","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Institute Giovanni Paolo II Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta Maria","family":"Antonacci","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Unit Sacco Hospital Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Palli","sequence":"additional","affiliation":[{"name":"Molecular and Nutritional Epidemiology Unit Cancer Research and Prevention Institute (ISPO) Florence 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