{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:34:30Z","timestamp":1790282070806,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T00:00:00Z","timestamp":1373846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Marginal zone B cells (<jats:styled-content style=\"fixed-case\">MZC<\/jats:styled-content>s) and monocytoid B cells (<jats:styled-content style=\"fixed-case\">MBC<\/jats:styled-content>s) appear to be related lymphoid cells that take part in reactive and neoplastic marginal zone proliferations. These lesions are not yet well characterized, and the aim of this study was to find better diagnostic criteria for them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We analysed 60 nodal lesions with <jats:styled-content style=\"fixed-case\">MBC<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">MZC<\/jats:styled-content> proliferation for their morphological, immunophenotypic, molecular genetic and <jats:italic><jats:styled-content style=\"fixed-case\">IG<\/jats:styled-content><\/jats:italic> gene rearrangement features. On the basis of the results of the rearrangement assay and immunoglobulin light chain restriction, the lesions were divided into reactive and neoplastic groups. Among the neoplastic lesions, polymorphic and monomorphic subgroups emerged. All reactive lesions had morphological features of the polymorphic subgroup. By immunohistochemistry, <jats:styled-content style=\"fixed-case\">IRTA<\/jats:styled-content>1 and\/or T\u2010bet expression was found in all reactive lesions and in 90% of neoplastic lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IRTA<\/jats:styled-content>1 and T\u2010bet are positive markers for the identification of <jats:styled-content style=\"fixed-case\">MZC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MBC<\/jats:styled-content> proliferations, and thus for the diagnosis of nodal marginal zone lymphoma (<jats:styled-content style=\"fixed-case\">NMZL<\/jats:styled-content>). Polymorphic and monomorphic subgroups of <jats:styled-content style=\"fixed-case\">NMZL<\/jats:styled-content> could be distinguished. Most morphological and immunophenotypic patterns in reactive and neoplastic nodal expansions of <jats:styled-content style=\"fixed-case\">MZC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">MBC<\/jats:styled-content>s overlapped. Therefore, <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> clonality assay of the immunoglobulin heavy and light chain gene loci is the most reliable method for their differentiation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12160","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T14:30:05Z","timestamp":1366122605000},"page":"482-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Nodal reactive and neoplastic proliferation of monocytoid and marginal zone B cells: an immunoarchitectural and molecular study highlighting the relevance of <scp>IRTA<\/scp>1 and T\u2010bet as positive markers"],"prefix":"10.1111","volume":"63","author":[{"given":"Roshanak","family":"Bob","sequence":"first","affiliation":[{"name":"Pathodiagnostik Berlin Berlin Reference and Consultation Centre for Lymphoma and Haematopathology Berlin Germany"},{"name":"Institute for Pathology Campus Benjamin Franklin Charite Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunangelo","family":"Falini","sequence":"additional","affiliation":[{"name":"Institute of Haematology Medicine University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Marafioti","sequence":"additional","affiliation":[{"name":"Department of Histopathology University College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C","family":"Paterson","sequence":"additional","affiliation":[{"name":"Department of Histopathology University College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pileri","sequence":"additional","affiliation":[{"name":"Unit of Haematopathology Department of Haematology and Oncological Sciences \u2018L. and A. 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