{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:25:40Z","timestamp":1762251940684},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T00:00:00Z","timestamp":1371081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess synaptophysin expression in columnar\u2010lined oesophageal mucosa showing either goblet cells, known as intestinal metaplasia, or with accompanying oxyntic glands or pyloric glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Of 159 biopsies, 53 were oesophageal (19 had intestinal metaplasia, 13 oxyntic glands, and 21 pyloric glands), 77 gastric (12 had goblet cells and 27 no goblet cells) and 29 duodenal. Synaptophysin\u2010positive goblet cells were found in all biopsies from the normal duodenum, in 53% of the oesophageal biopsies showing intestinal metaplasia, but only in 8% of gastric biopsies showing intestinal metaplasia. Synaptophysin\u2010positive Paneth cells occurred in all duodenal biopsies, and in nine of the gastric biopsies showing intestinal metaplasia, but in only one of the oesophageal biopsies showing intestinal metaplasia. A continuous synaptophysin\u2010positive neck cell zone was found in all biopsies from the normal antrum, but in none of the oesophageal biopsies with pyloric glands or with chronic antritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The paucity or absence of synaptophysin\u2010positive cells in all three phenotypes of Barrett's mucosa might mirror a sequela of chronic inflammation caused by the particular pathogenic bacteria present in the immediate oesophageal microenvironment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12168","type":"journal-article","created":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T17:40:54Z","timestamp":1366652454000},"page":"208-216","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Paucity of synaptophysin\u2010expressing cells in <scp>B<\/scp>arrett's mucosa"],"prefix":"10.1111","volume":"63","author":[{"given":"Carlos A","family":"Rubio","sequence":"first","affiliation":[{"name":"Gastrointestinal and Liver Pathology Research Laboratory Department of Pathology Karolinska Institute and University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Kaufeldt","sequence":"additional","affiliation":[{"name":"Gastrointestinal and Liver Pathology Research Laboratory Department of Pathology Karolinska Institute and University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608073150605"},{"key":"e_1_2_6_3_1","first-page":"3115","article-title":"The length of the Barrett's mucosa in baboons, revisited","volume":"32","author":"Rubio CA","year":"2012","journal-title":"Anticancer Res."},{"key":"e_1_2_6_4_1","first-page":"418","article-title":"Specialized metaplastic columnar epithelium in Barrett's esophagus. A comparative transmission electron microscopic study","volume":"60","author":"Levine DS","year":"1989","journal-title":"Lab. Invest."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00362.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.083600"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(11)60588-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000235923"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2011.01270.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2007.00744.x"},{"key":"e_1_2_6_11_1","first-page":"279","volume-title":"Stem cell, regenerative medicine and cancer","author":"Rubio CA","year":"2011"},{"key":"e_1_2_6_12_1","first-page":"5115","article-title":"Lysozyme is up\u2010regulated in columnar\u2010lined Barrett's mucosa: a possible natural defence mechanism against Barrett's esophagus\u2010associated pathogenic bacteria","volume":"32","author":"Rubio CA","year":"2012","journal-title":"Anticancer Res."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2009.03.011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i46.7277"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/518578"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.04.046"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(83)80045-8"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711460310"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1987.tb02608.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880081"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689690401200204"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-00456"},{"key":"e_1_2_6_23_1","first-page":"3411","article-title":"Chaperon normal goblet cells intercalated with dysplastic cells in duodenal adenomas express synaptophysin","volume":"32","author":"Rubio CA","year":"2012","journal-title":"Anticancer Res."},{"key":"e_1_2_6_24_1","first-page":"135","article-title":"Paneth cells and goblet cells express the neuroendocrine peptide synaptophysin I. Normal duodenal mucosa","volume":"26","author":"Rubio CA","year":"2012","journal-title":"In Vivo"},{"key":"e_1_2_6_25_1","first-page":"149","article-title":"Gastric neuroendocrine cells and secretory products","volume":"71","author":"\u00d6berg K","year":"1998","journal-title":"Yale J. Biol. Med."},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.03867.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004180050332"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.039008"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12012"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.85"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12168","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.12168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:23:09Z","timestamp":1696360989000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.12168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,13]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/his.12168"],"URL":"https:\/\/doi.org\/10.1111\/his.12168","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,13]]},"assertion":[{"value":"2013-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}