{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:45:30Z","timestamp":1791301530063,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T00:00:00Z","timestamp":1376438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Secretory carcinoma (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>) is a rare histological type of breast cancer, and <jats:italic><jats:styled-content style=\"fixed-case\">ETV<\/jats:styled-content>6\u2013<jats:styled-content style=\"fixed-case\">NTRK<\/jats:styled-content>3<\/jats:italic> gene fusion is highly specific to it. The differential diagnoses of <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> include acinic cell carcinoma (<jats:styled-content style=\"fixed-case\">ACCA<\/jats:styled-content>) and cystic hypersecretory carcinoma (<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>), as well as invasive ductal carcinoma (<jats:styled-content style=\"fixed-case\">IDC<\/jats:styled-content>). For patients with these rare but distinctive histological subtypes, <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> and its histopathological mimics should be differentiated from each other. However, differential markers have not yet been assessed systematically, and we aimed to identify and evaluate novel and existing markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We reviewed 19 cases diagnosed initially as <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> using integrated diagnostic techniques, including morphology, immunohistochemistry and molecular pathology, and validated promising markers in 445 breast cancers. We reclassified 19 formerly diagnosed \u2018<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>s\u2019 into nine <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>s, three <jats:styled-content style=\"fixed-case\">ACCA<\/jats:styled-content>s, three <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>s, three <jats:styled-content style=\"fixed-case\">IDC<\/jats:styled-content>s and one microglandular adenosis. We confirmed that <jats:italic><jats:styled-content style=\"fixed-case\">ETV<\/jats:styled-content>6\u2013<jats:styled-content style=\"fixed-case\">NTRK<\/jats:styled-content>3<\/jats:italic> gene rearrangement and amylase positivity are good diagnostic markers for <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ACCA<\/jats:styled-content>, respectively. Vacuolar staining for adipophilin, positivity for \u03b1\u2010lactalbumin and negativity for <jats:italic><jats:styled-content style=\"fixed-case\">ETV<\/jats:styled-content>6<\/jats:italic> rearrangement are diagnostic markers for <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, we propose a panel of four markers (<jats:italic><jats:styled-content style=\"fixed-case\">ETV<\/jats:styled-content>6<\/jats:italic> rearrangement, amylase, \u03b1\u2010lactalbumin and adipophilin) for distinguishing <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ACCA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CHC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IDC<\/jats:styled-content>. This simple but robust panel will serve pathologists well as a practical guide for reaching an appropriate diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12172","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T16:12:20Z","timestamp":1366819940000},"page":"509-519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Secretory carcinoma of the breast and its histopathological mimics: value of markers for differential diagnosis"],"prefix":"10.1111","volume":"63","author":[{"given":"Tomo","family":"Osako","sequence":"first","affiliation":[{"name":"Division of Pathology The Cancer Institute Japanese Foundation for Cancer Research Tokyo Japan"},{"name":"Department of Pathology The Cancer Institute Hospital Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Pathology The Cancer Institute Japanese Foundation for Cancer Research Tokyo Japan"},{"name":"Pathology Project for Molecular Targets The Cancer Institute Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Horii","sequence":"additional","affiliation":[{"name":"Department of Pathology The Cancer Institute Hospital Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Iwase","sequence":"additional","affiliation":[{"name":"Breast Oncology Center The Cancer Institute Hospital Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Futoshi","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Division of Pathology The Cancer Institute Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1966.03100050096033"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197010)26:4<953::AID-CNCR2820260433>3.0.CO;2-R"},{"key":"e_1_2_7_4_1","volume-title":"Who classification of tumours of the breast","author":"Lakhani SR","year":"2012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00429608"},{"key":"e_1_2_7_6_1","first-page":"475","article-title":"Secretory carcinoma of the breast: light microscopical, immunohistochemical and flow cytometric study","volume":"7","author":"Lamovec J","year":"1994","journal-title":"Mod. 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