{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:07:57Z","timestamp":1791338877075,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T00:00:00Z","timestamp":1372032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess how hybridization probe design may affect <jats:italic><jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic> status determination in Burkitt lymphoma and diffuse large B\u2010cell lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We compared the results obtained with one dual\u2010fusion and two break\u2010apart commercial probes in a retrospective series of 91 aggressive B\u2010cell lymphomas. All three probes were able to detect the <jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic> translocation in every case bearing it (13\/13). However, seven of 13 (54%) non\u2010<jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic> (light\u2010chain immunoglobulin or non\u2010immunoglobulin\u2010<jats:italic><jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic>) rearrangements were unambiguously detected by just one of the probes tested. On the other hand, when the <jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic> dual\u2010fusion probe was used, nine of 15 (60%) cases with a hybridization pattern suggestive of a non\u2010<jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic> translocation were attributable to <jats:italic><jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic> copy gain rather than <jats:italic><jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic> rearrangement, as demonstrated by both break\u2010apart probes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Taking into account the prognostic and therapeutic implications of the <jats:italic><jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic> translocation, probe design and limitations should be particularly kept in mind when <jats:italic><jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic> hybridization patterns are interpreted. In our experience, detection of 8q24 abnormalities could be optimized by a two\u2010probe approach involving the application of both <jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic> dual\u2010fusion and <jats:italic><jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic> break\u2010apart selected kits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12178","type":"journal-article","created":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T10:00:38Z","timestamp":1367575238000},"page":"418-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["<i><scp>MYC<\/scp><\/i> status determination in aggressive <scp>B<\/scp>\u2010cell lymphoma: the impact of <scp>FISH<\/scp> probe selection"],"prefix":"10.1111","volume":"63","author":[{"given":"Ana M","family":"Mu\u00f1oz\u2010M\u00e1rmol","sequence":"first","affiliation":[{"name":"Department of Pathology Hospital Universitari Germans Trias i Pujol Badalona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitari Germans Trias i Pujol Badalona Barcelona Spain"},{"name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Germans Trias i Pujol (IGTP) Badalona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Tapia","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitari Germans Trias i Pujol Badalona Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Marginet","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitari Germans Trias i Pujol Badalona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelio","family":"Ariza","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitari Germans Trias i Pujol Badalona Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L","family":"Mate","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitari Germans Trias i Pujol Badalona Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,24]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"World Health Organization classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.8385"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2010.08.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.3947"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-220095"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.0985"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.4342"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-406033"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.21.3707"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61177-X"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055351"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.281"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/1.8.625"},{"key":"e_1_2_7_15_1","first-page":"6547","article-title":"Mapping chromosomal breakpoints of Burkitt's t(8;14) translocations far upstream of c\u2010myc","volume":"52","author":"Joos S","year":"1992","journal-title":"Cancer Res."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404753"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404340"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404529"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03978.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033813"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318244e2ba"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10211"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12308-008-0017-5"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20009"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.000968"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2009.12.010"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.520772"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2006.050083"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200015"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2011.01.004"},{"key":"e_1_2_7_31_1","volume-title":"Mitelman database of chromosome aberrations and gene fusions in cancer","author":"Mitelman F","year":"2012"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12178","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.12178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T23:23:31Z","timestamp":1696375411000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.12178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,24]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/his.12178"],"URL":"https:\/\/doi.org\/10.1111\/his.12178","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,24]]},"assertion":[{"value":"2013-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}