{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:08:30Z","timestamp":1784120910262,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T00:00:00Z","timestamp":1373241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Immature squamous metaplasia of the pancreatic duct (<jats:styled-content style=\"fixed-case\">ISMPD<\/jats:styled-content>) can be difficult to differentiate from an intraductal carcinoma of the pancreas (<jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content>), and little is known about the pathological nature of <jats:styled-content style=\"fixed-case\">ISMPD<\/jats:styled-content>. The aim of this study was to analyse 20 <jats:styled-content style=\"fixed-case\">ISMPD<\/jats:styled-content> and 10 <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content> tissue samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ISMPD<\/jats:styled-content> shares some characteristics with <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content>. Seven of 20 <jats:styled-content style=\"fixed-case\">ISMPD<\/jats:styled-content> samples were covered by a layer of pancreatic duct epithelium, whereas this was not seen in the <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content> samples. Immunohistochemistry of <jats:styled-content style=\"fixed-case\">ISMPD<\/jats:styled-content> revealed positivity for p63 (100%), cytokeratin 5\/6 (95%), cytokeratin 7 (95%), cytokeratin 20 (10%), and <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>\u20101 (95%), and the samples were negative for p53, carcinoembryonic antigen (<jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>), and bcl\u20102. In contrast, <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content> was positive for p63 (40%), p53 (10%), cytokeratin 7 (90%), cytokeratin 20 (20%), <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> (30%), and <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>\u20101 (80%), and negative for cytokeratin 5\/6. However, in 84% (16) of the <jats:styled-content style=\"fixed-case\">ISMPD<\/jats:styled-content> samples, cytokeratin 7 was expressed only by an epithelial layer at the apical surface; this expression pattern was not found in any of the 10 <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content> samples. The mean <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i67 labelling index was 1.0% in <jats:styled-content style=\"fixed-case\">ISMPD<\/jats:styled-content> and 18.5% in <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that immunohistochemical staining for cytokeratin 5\/6 and <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i67 constitutes the best combination for differentiating <jats:styled-content style=\"fixed-case\">ISMPD<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12180","type":"journal-article","created":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T10:00:36Z","timestamp":1367575236000},"page":"343-350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immature squamous metaplasia (focal atypical epithelial hyperplasia) of the pancreatic duct\u2014immunohistochemical distinction from intraductal carcinoma"],"prefix":"10.1111","volume":"63","author":[{"given":"Kunio","family":"Mochizuki","sequence":"first","affiliation":[{"name":"Department of Pathology Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Pathology Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Oishi","sequence":"additional","affiliation":[{"name":"Department of Pathology Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Pathology Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadao","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Yamane","sequence":"additional","affiliation":[{"name":"Department of Pathology Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Katoh","sequence":"additional","affiliation":[{"name":"Department of Pathology Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,8]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"223","volume-title":"Atlas of tumor pathology. 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