{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:19:25Z","timestamp":1783473565951,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Oesophageal hyperkeratosis is rarely described. In contrast to hyperkeratosis of orolaryngeal mucosa, where its risk factors and association with squamous neoplasia are well\u2010studied, the prevalence and clinicopathological features of oesophageal hyperkeratosis are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We reviewed prospectively 1845 oesophageal biopsies and found hyperkeratosis in 37 (2.0%). Among 98 patients studied, hyperkeratosis occurred in two distinct settings: group 1 [within Barrett's oesophagus (<jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>)\/adenocarcinoma, <jats:italic>n\u00a0<\/jats:italic>=\u00a061, 62%] and group 2 (outside <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>\/adenocarcinoma, <jats:italic>n\u00a0<\/jats:italic>=\u00a037, 38%). In contrast to group 1, hyperkeratosis in group 2 was more often multifocal (&gt;3 foci in 51% versus 16%, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.0001), involved mid\u2010oesophagus (51% versus 2%, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001), showed endoscopic leucoplakia (24% versus 3%, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.003) and involved current\/former alcohol users (51% versus 19%, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.0012). Importantly, invasive squamous carcinoma and squamous dysplasia were seen only in group 2 (47% and 19% versus 0%, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001). Further, 42% of group 2, but none of group 1, had benign or malignant squamous lesions of the oral cavity\/larynx (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hyperkeratosis involves ~2% of oesophageal biopsies and can be divided into cases occurring within <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>\/adenocarcinoma and those occurring outside <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>\/adenocarcinoma. The former lack clinical significance, whereas the latter are associated frequently with oesophageal squamous neoplasia and squamous pathology of the head and neck region.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12195","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T08:24:38Z","timestamp":1369038278000},"page":"463-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Oesophageal hyperkeratosis: clinicopathological associations"],"prefix":"10.1111","volume":"63","author":[{"given":"Melissa W","family":"Taggart","sequence":"first","affiliation":[{"name":"Department of Pathology University of Texas M. D. Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas M. D. Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition University of Texas M. D. Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan C","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas M. D. 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