{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:02:03Z","timestamp":1791500523589,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:00:00Z","timestamp":1379635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Muscle satellite cells (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>s) are responsible for the regenerative events following muscle fibre injury. This study aimed to improve our understanding of <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> behaviour in two models of muscle disorder with different pathological mechanisms and onset of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Pax7<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> content was assessed in types I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> fibres of patients with Duchenne muscular dystrophy (<jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>;<jats:italic> n\u00a0<\/jats:italic>=\u00a09; age 13\u00a0\u00b1\u00a02\u00a0years), polymyositis\/dermatomyositis (<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>;<jats:italic> n\u00a0<\/jats:italic>=\u00a09; age 52\u00a0\u00b1\u00a012\u00a0years) and in controls (<jats:italic>n\u00a0<\/jats:italic>=\u00a05; age 26\u00a0\u00b1\u00a05\u00a0years). Pax7<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>s number in type I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> fibres was higher (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05) in <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content> and in <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> compared to controls. Type I fibres were associated with a higher number of Pax7<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>s compared to type <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> fibres only in <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>; Pax7<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>s number in type I fibres was about threefold higher in <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05). In <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>, Pax7<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> content in small regenerating fibres (0.09\u00a0\u00b1\u00a00.09 <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>s\/fibre) was similar to that in fibres from healthy skeletal muscle. The proportion of activated <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>s (Ki\u201067<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>s) was fivefold lower in <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content> (0.4\u00a0\u00b1\u00a00.4%) compared to <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> (2.8\u00a0\u00b1\u00a02%). Pax7<jats:sup>+<\/jats:sup> cells located outside the basal lamina were observed in <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content> muscles only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The capacity to generate new <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>s is increased even in severely impaired muscles and a fibre type\u2010specific enhancement of <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> occurs in type I muscle fibres in <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12231","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T09:49:10Z","timestamp":1374227350000},"page":"826-832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Fibre type\u2010specific satellite cell content in two models of muscle disease"],"prefix":"10.1111","volume":"63","author":[{"given":"Landry\u2010Cyrille","family":"Bankol\u00e9","sequence":"first","affiliation":[{"name":"Muscle and Exercise Physiology Research Group (MEP\u2010RG) School of Health and Medical Sciences \u00d6rebro University \u00d6rebro Sweden"},{"name":"Laboratory of Exercise Physiology (LPE EA 4338) University of Lyon Saint\u2010\u00c9tienne France"},{"name":"Unit of Myology University Hospital of Saint\u2010Etienne Saint\u2010\u00c9tienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9onard","family":"Feasson","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Physiology (LPE EA 4338) University of Lyon Saint\u2010\u00c9tienne France"},{"name":"Unit of Myology University Hospital of Saint\u2010Etienne Saint\u2010\u00c9tienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Ponsot","sequence":"additional","affiliation":[{"name":"Muscle and 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