{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:51:10Z","timestamp":1761519070102},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T00:00:00Z","timestamp":1378339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>In a previous report, we proposed that analysis of 53<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>1 expression by immunofluorescence could be a useful tool in estimating the level of genomic instability (<jats:styled-content style=\"fixed-case\">GIN<\/jats:styled-content>), as well as the malignant potential, of thyroid tumours. In an attempt to clarify the value of 53<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>1 expression as a new molecular marker for the aggressiveness of thyroid papillary microcarcinoma (<jats:styled-content style=\"fixed-case\">PMC<\/jats:styled-content>), we assessed the association between the type of 53<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>1 expression and clinicopathological features such as tumour size, extrathyroidal invasion, lymph node metastasis and <jats:styled-content style=\"fixed-case\"><jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V<\/jats:italic><\/jats:sup><\/jats:styled-content><jats:sup><jats:italic>600E<\/jats:italic><\/jats:sup> mutation of <jats:styled-content style=\"fixed-case\">PMC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A total of 36 surgically resected thyroid tumours, including 13 <jats:styled-content style=\"fixed-case\">PMC<\/jats:styled-content> and 23 conventional papillary thyroid carcinomas (<jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content>), were available for this study. Analysis using immunofluorescence revealed that the incidence of an abnormal or high <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage response (<jats:styled-content style=\"fixed-case\">DDR<\/jats:styled-content>) type of 53<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>1 expression was significantly higher in <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">PMC<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\"><jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V<\/jats:italic><\/jats:sup><\/jats:styled-content><jats:sup><jats:italic>600E<\/jats:italic><\/jats:sup> mutation was not associated significantly with tumour aggressiveness in either <jats:styled-content style=\"fixed-case\">PMC<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> cases. Abnormal\/high <jats:styled-content style=\"fixed-case\">DDR<\/jats:styled-content> type of 53<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>1 expression was associated closely with both <jats:styled-content style=\"fixed-case\"><jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V<\/jats:italic><\/jats:sup><\/jats:styled-content><jats:sup><jats:italic>600E<\/jats:italic><\/jats:sup> mutation and papillary and\/or trabecular architecture of <jats:styled-content style=\"fixed-case\">PMC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abnormal\/high <jats:styled-content style=\"fixed-case\">DDR<\/jats:styled-content> type of 53<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>1 expression might be associated with <jats:styled-content style=\"fixed-case\">GIN<\/jats:styled-content> and papillary\/trabecular morphology at an early stage of <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> carcinogenesis through <jats:styled-content style=\"fixed-case\"><jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V<\/jats:italic><\/jats:sup><\/jats:styled-content><jats:sup><jats:italic>600E<\/jats:italic><\/jats:sup> mutation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12233","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T15:47:47Z","timestamp":1374248867000},"page":"726-734","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Significance of p53\u2010binding protein 1 (53<scp>BP<\/scp>1) expression in thyroid papillary microcarcinoma: association with <scp><i>BRAF<\/i><sup><i>V<\/i><\/sup><\/scp><sup><i>600E<\/i><\/sup> mutation status"],"prefix":"10.1111","volume":"63","author":[{"given":"Zhanna","family":"Mussazhanova","sequence":"first","affiliation":[{"name":"Department of Tumor and Diagnostic Pathology Atomic Bomb 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