{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:35:20Z","timestamp":1761708920655,"version":"3.37.3"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:00:00Z","timestamp":1381276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Spanish Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"crossref","award":["PTA2011"],"award-info":[{"award-number":["PTA2011"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To describe an unusual pattern of epithelial membrane antigen (<jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content>) immunoreactivity in highly proliferative human <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ergmann glia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>An immunohistochemical study was performed of postmortem cerebellar tissue from 18 adult patients with cerebellar damage of various aetiologies and 15 biopsies of diverse adult and paediatric cerebellar tumours. We observed marked proliferation of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ergmann glia with unusual prominent dot\u2010like cytoplasmic <jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content> immunoreactivity in a case with extensive leptomeningeal sarcomatosis. Similar staining was not observed in association with other types of cerebellar pathology, except for other neoplastic conditions, such as leptomeningeal carcinomatosis, adult medulloblastoma, and pilocytic astrocytoma in children. At an ultrastructural level, the index case showed prominent endoplasmic reticulum with some intermediate filaments and lipofuscin granules, but no structures related to cilia or microvilli were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We consider that prominent <jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content> dots in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ergmann glia might represent excessive activation induced by an overlying leptomeningeal tumour that stimulates the expression of early developmental antigens. This observation suggests modulation of the glial phenotype when exposed to a neoplastic microenvironment that, in turn, might influence the regenerative potential of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ergmann glia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12260","type":"journal-article","created":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T16:15:16Z","timestamp":1377015316000},"page":"445-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prominent <scp>EMA<\/scp> \u2018dots\u2019 in tumour\u2010induced <scp>B<\/scp>ergmann gliosis"],"prefix":"10.1111","volume":"64","author":[{"given":"Ellen","family":"Gelpi","sequence":"first","affiliation":[{"name":"Neurological Tissue Bank of the Biobanc Hospital Clinic Insitut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep A","family":"Bombi","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Clinic University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Martinez\u2010Saez","sequence":"additional","affiliation":[{"name":"Pathology Department Vall d'Hebron Resarch Institute Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Caral","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hospital Clinic University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Ribalta","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Clinic University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2009.06.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1201\/b22602"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749\u20108104\u20102\u201026"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(85)80132-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687763"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-003-0752-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007427"},{"key":"e_1_2_7_9_1","first-page":"212","article-title":"The ultrastructure of ependymoma: personal experience and the review of the literature","volume":"34","author":"Liberski PP","year":"1996","journal-title":"Folia Neuropathol."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5586-06.2007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2008.05.010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00195605"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12260","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.12260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:39:32Z","timestamp":1696405172000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.12260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,9]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/his.12260"],"URL":"https:\/\/doi.org\/10.1111\/his.12260","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"type":"print","value":"0309-0167"},{"type":"electronic","value":"1365-2559"}],"subject":[],"published":{"date-parts":[[2013,10,9]]},"assertion":[{"value":"2013-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}