{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:52:53Z","timestamp":1788900773701,"version":"build-2803163510"},"reference-count":140,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>\n                    The interpretation of colorectal biopsies taken for the initial diagnosis of chronic idiopathic inflammatory bowel disease (\n                    <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                    ) is challenging. Subclassification of\n                    <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                    as ulcerative colitis (\n                    <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                    ) or\n                    <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                    rohn's disease, which may be particularly difficult, is the subject of this review. Biopsies taken at first presentation are emphasised, partly because their features have not been modified by time or treatment. Aspects of longstanding disease and of resections are also mentioned. The first part of the review comprises background considerations and a summary of histological features that are discriminant, according to published evidence, between\n                    <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                    rohn's disease in initial biopsies. Pitfalls and problems associated with making the distinction between\n                    <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                    rohn's disease are then discussed. These include: mimics of\n                    <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                    ; inadequate clinical details; unreliable microscopic features; absence of histological changes in early\n                    <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                    ; discontinuity in\n                    <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                    ; cryptolytic granulomas; differences between paediatric and adult\n                    <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                    ; reliance on ileal and oesophagogastroduodenal histology; and atypical features in\n                    <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                    resections. Avoidance by pathologists of known pitfalls should increase the likelihood of accurate and confident subclassification of\n                    <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                    , which is important for optimum medical and surgical management.\n                  <\/jats:p>","DOI":"10.1111\/his.12263","type":"journal-article","created":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T04:28:45Z","timestamp":1377491325000},"page":"317-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Ulcerative colitis or\n                    <scp>C<\/scp>\n                    rohn's disease? 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