{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:18:28Z","timestamp":1791166708371,"version":"4.1.0"},"reference-count":214,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T00:00:00Z","timestamp":1383696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    Many soft tissue sarcomas have chromosomal translocations with resultant formation of new fusion genes. Among the genes that can be rearranged, the\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EWSR<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    gene has been identified as a partner in a wide variety of clinically and pathologically diverse sarcomas as well as some non\u2010mesenchymal tumours. The former include Ewing sarcoma and similar (Ewing\u2010like) small round cell sarcomas, desmoplastic small round cell tumour, myxoid liposarcoma, extraskeletal myxoid chondrosarcoma, angiomatoid fibrous histiocytoma, clear cell sarcoma of soft tissue and clear cell sarcoma\u2010like tumours of the gastrointestinal tract, primary pulmonary myxoid sarcoma, extrasalivary myoepithelial tumours and sporadic examples of low\u2010grade fibromyxoid sarcoma, sclerosing epithelioid fibrosarcoma and mesothelioma.\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EWSR<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    is a \u2018promiscuous\u2019 gene that can fuse with many different partner genes, but sometimes this results in phenotypically identical tumours.\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EWSR<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    can, conversely, partner with the same genes in morphologically and behaviourally different neoplasms. This paper reviews the diversity of the several soft tissue tumour types that are associated with rearrangement of the\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EWSR<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    gene.\n                  <\/jats:p>","DOI":"10.1111\/his.12269","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T09:04:39Z","timestamp":1377767079000},"page":"134-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":159,"title":["The diversity of soft tissue tumours with\n                    <i>\n                      <scp>EWSR<\/scp>\n                      1\n                    <\/i>\n                    gene rearrangements: a review"],"prefix":"10.1111","volume":"64","author":[{"given":"Cyril","family":"Fisher","sequence":"first","affiliation":[{"name":"Royal Marsden Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2091"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2883"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgn017"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204598"},{"key":"e_1_2_11_6_1","first-page":"2837","article-title":"Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor","volume":"54","author":"Ladanyi M","year":"1994","journal-title":"Cancer Res."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.4.1028"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199802000-00005"},{"key":"e_1_2_11_9_1","first-page":"489","article-title":"Fusion of the EWS and CHOP genes in myxoid liposarcoma","volume":"12","author":"Panagopoulos I","year":"1996","journal-title":"Oncogene"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199708)182:4<437::AID-PATH882>3.0.CO;2-X"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60698-8"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.07.085"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2011.480"},{"key":"e_1_2_11_14_1","first-page":"229","article-title":"Fusion of the EWS gene to CHN, a member of the steroid\/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma","volume":"12","author":"Clark J","year":"1996","journal-title":"Oncogene"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.12.2219"},{"key":"e_1_2_11_16_1","first-page":"765","article-title":"t(9;22)(q22\u201031;q11\u201012) is a consistent marker of extraskeletal myxoid chondrosarcoma: evaluation of three cases","volume":"8","author":"Sciot R","year":"1995","journal-title":"Mod. 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