{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:41:43Z","timestamp":1775094103796,"version":"3.50.1"},"reference-count":95,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T00:00:00Z","timestamp":1383177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Alongside histomorphology and immunohistochemistry, molecular pathology is now established as one of the cornerstones in the tissue diagnosis of bone tumours. We describe the principal molecular pathological techniques employed, and each of the bone tumour entities where their identified characteristic molecular pathological changes can be detected to support and confirm the suspected histological diagnosis. Tumours discussed include fibrous dysplasia, classical and subtype osteosarcomas, central and surface cartilaginous tumours, <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>wing's sarcoma, vascular tumours, aneurysmal bone cyst, chordoma, myoepithelioma, and angiomatoid fibrous histiocytoma. This is a rapidly evolving field with discoveries occurring every few months, and some of the newer entities (the <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>wing's\u2010like sarcomas), which are principally identified by their molecular pathology characteristics, are discussed.<\/jats:p>","DOI":"10.1111\/his.12275","type":"journal-article","created":{"date-parts":[[2013,9,7]],"date-time":"2013-09-07T15:51:20Z","timestamp":1378569080000},"page":"461-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Molecular pathology of bone tumours: diagnostic implications"],"prefix":"10.1111","volume":"64","author":[{"given":"Florian","family":"Puls","sequence":"first","affiliation":[{"name":"Department of Musculoskeletal Pathology Royal Orthopaedic Hospital NHS Trust Robert Aitken Institute of Clinical Research Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela J","family":"Niblett","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Pathology Royal Orthopaedic Hospital NHS Trust Robert Aitken Institute of Clinical Research Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D Chas","family":"Mangham","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Pathology Royal Orthopaedic Hospital NHS Trust Robert Aitken Institute of Clinical Research Birmingham UK"},{"name":"Department of Musculoskeletal Pathology Robert Jones &amp; Agnes Hunt Orthopaedic Hospital NHS Trust Oswestry Shropshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02318.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-947-5_17"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.97"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.124"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2009.10.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(01)00563-5"},{"key":"e_1_2_8_8_1","volume-title":"World Health Organization classification of tumours of soft tissue and bone","author":"Fletcher CDM","year":"2013"},{"key":"e_1_2_8_9_1","volume-title":"Dahlin's bone tumors","author":"Unni KK","year":"2010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03097.x"},{"key":"e_1_2_8_11_1","volume-title":"Diagnostic pathology: bone","author":"Nielsen GP","year":"2013"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02676.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2010.10.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.09.012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.223"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.00160"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-013-1437-x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.229"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.055"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.10.010"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3352"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2012.08.004"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20923"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.1219"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31824230d0"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20761"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04023.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202346"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2913"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31827ab703"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2668"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.132738.111"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08617"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10866"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.994"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1004"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.01.012"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04010.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2009.00352.x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk067"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1086\/302532"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.311"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-005-1266-7"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.02.008"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20937"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12022"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049705"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182796e46"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-010-1023-4"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2012.06.006"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000167056.13614.62"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-011-1138-2"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2011.07.008"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.5845"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.3585"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203762"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2007.070053"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2184"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90012-6"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800755"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/PDM.0b013e3181a06f66"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800486"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2010.076133"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2010.03.005"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1107"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl136"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.04.023"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20945"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2009.06.015"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20886"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002409"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2011.10.008"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199611000-00001"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22073"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2827"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63432-3"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208506"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2011.118"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2005-6-9-r76"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1969"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4082"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.454"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2816"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2419"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31815b693a"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-007-0435-y"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31824f4ce3"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20819"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182858a0e"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20171"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000176434.19197.c1"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cb4017"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-010-1023-0"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318227e4d2"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1236062"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11005"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12275","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.12275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:11:06Z","timestamp":1695571866000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.12275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,31]]},"references-count":95,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/his.12275"],"URL":"https:\/\/doi.org\/10.1111\/his.12275","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,31]]},"assertion":[{"value":"2013-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}