{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:05:27Z","timestamp":1789891527234,"version":"4.0.1"},"reference-count":113,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T00:00:00Z","timestamp":1385596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    The discovery of activating mutations in the tyrosine kinase receptor genes\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">PDGFRA<\/jats:styled-content>\n                    <\/jats:italic>\n                    has led to the development of effective targeted therapies for gastrointestinal stromal tumours (\n                    <jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>\n                    s). Specific genotypes, in part, predict the response to treatment with tyrosine kinase inhibitors. However, ~10% of\n                    <jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>\n                    s lack such mutations (often referred to as \u2018wild\u2010type\u2019\n                    <jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>\n                    s). Recent insights into the biology of \u2018wild\u2010type\u2019\n                    <jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>\n                    s have resulted in clinically significant subclassification of this heterogeneous group of tumours, a large subset of which are now known to represent succinate dehydrogenase\u2010deficient\n                    <jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>\n                    s. Recognition of this distinctive class of tumours has critical implications for prognosis, therapy, clinical follow\u2010up, and genetic counselling. Other uncommon genetic groups include neurofibromatosis type I\u2010associated and\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\n                    <\/jats:italic>\n                    \u2010mutant\n                    <jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>\n                    s. This review provides an update on the diagnosis and pathogenesis of these less common classes of\n                    <jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>\n                    s, summarizes the clinical and pathological features associated with particular genotypes, and discusses mechanisms of resistance to targeted therapies.\n                  <\/jats:p>","DOI":"10.1111\/his.12302","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T22:26:07Z","timestamp":1381530367000},"page":"53-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Gastrointestinal stromal tumours: from\n                    <scp>KIT<\/scp>\n                    to succinate dehydrogenase"],"prefix":"10.1111","volume":"64","author":[{"given":"Leona A","family":"Doyle","sequence":"first","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital  Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason L","family":"Hornick","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital  Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.09.009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20862"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i14.2223"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196001\/02)13:1<25::AID-CNCR2820130106>3.0.CO;2-J"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197701)39:1<255::AID-CNCR2820390139>3.0.CO;2-H"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196911)24:5<996::AID-CNCR2820240519>3.0.CO;2-Y"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711530107"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198705000-00007"},{"key":"e_1_2_8_10_1","first-page":"1259","article-title":"Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal","volume":"152","author":"Kindblom LG","year":"1998","journal-title":"Am. 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