{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T07:55:32Z","timestamp":1776498932015,"version":"3.51.2"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T00:00:00Z","timestamp":1389916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Decorin and biglycan are members of the small leucine\u2010rich proteoglycan family, and constituents of both the extracellular matrix (<jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>) and the cell surface. They are recognized as important factors in the control of proliferation, migration and invasion <jats:italic>in\u00a0vivo<\/jats:italic> and <jats:italic>in\u00a0vitro<\/jats:italic>. In this study, the localization patterns of decorin and biglycan were determined in healthy placentas and in highly invasive placental pathologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The study included immunolocalization of decorin and biglycan in samples of first\u2010trimester and term placentas, placenta accreta, invasive mole, and choriocarcinoma. Extravillous cytotrophoblast (<jats:styled-content style=\"fixed-case\">EVT<\/jats:styled-content>) cells were positive for both proteoglycans in all pathologies and in first\u2010trimester placentas, although not in term placentas. Biglycan was immunolocalized in the <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content> of all healthy and pathological placentas, whereas decorin was observed only in term placenta <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The expression of both proteoglycans was cell\u2010specific and gestation time\u2010dependent in healthy placentas, and was associated with invasive <jats:styled-content style=\"fixed-case\">EVT<\/jats:styled-content> cells in pathological placentas. In view of the biological properties of these molecules, it is possible that the biglycan pattern found here is intrinsically implicated in the invasive activity of <jats:styled-content style=\"fixed-case\">EVT<\/jats:styled-content> cells in both healthy and disordered placentas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12304","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:38:16Z","timestamp":1381545496000},"page":"616-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Decorin and biglycan immunolocalization in non\u2010villous structures of healthy and pathological human placentas"],"prefix":"10.1111","volume":"64","author":[{"given":"Alexandre U","family":"Borbely","sequence":"first","affiliation":[{"name":"Department of Cell and Developmental Biology Institute of Biomedical Sciences University of Sao Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Daher","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Federal University of Sao Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia M","family":"Ishigai","sequence":"additional","affiliation":[{"name":"Department of Pathology Paulista Medical School Federal University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosiane","family":"Mattar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Federal University of Sao Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue Y","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Federal University of Sao Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Kn\u00f6fler","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal\u2010Maternal Medicine Reproductive Biology Unit Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estela","family":"Bevilacqua","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology Institute of Biomedical Sciences University of Sao Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio F","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Federal University of Sao Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI846"},{"key":"e_1_2_7_3_1","first-page":"365","volume-title":"Extracellular matrix, anchor, and adhesion proteins","author":"Fisher L","year":"1999"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00808"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.118.6.1523"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.67.1.609"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/346281a0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503833200"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01810677"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0897.2003.00099.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02845-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4004(95)90110-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod67.2.681"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0780"},{"key":"e_1_2_7_15_1","volume-title":"World Health Organization classification of tumours: pathology and genetics. 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