{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T19:00:58Z","timestamp":1772305258867,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T00:00:00Z","timestamp":1386806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To look for <jats:italic><jats:styled-content style=\"fixed-case\">FOXL<\/jats:styled-content>2<\/jats:italic> mutation in rare ovarian epithelial lesions showing stromal components with morphological features of adult granulosa cell tumour (<jats:styled-content style=\"fixed-case\">AGCT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We report the 402C\u2192<jats:styled-content style=\"fixed-case\">G <\/jats:styled-content><jats:italic><jats:styled-content style=\"fixed-case\">FOXL<\/jats:styled-content>2<\/jats:italic> mutation status in five epithelial ovarian lesions in women aged 45\u201377\u00a0years showing stromal proliferations that were morphologically indistinguishable from <jats:styled-content style=\"fixed-case\">AGCT<\/jats:styled-content>. The lesions were mucinous cystadenoma, mixed epithelial cystadenoma, endometriotic cyst, mucinous borderline tumour (intestinal type), and mucinous carcinoma. In one case, the <jats:styled-content style=\"fixed-case\">AGCT<\/jats:styled-content> component formed a discrete nodule, and in the others it was distributed within the septa and cyst walls. <jats:italic><jats:styled-content style=\"fixed-case\">FOXL<\/jats:styled-content>2<\/jats:italic> mutation was present in two cases and absent in three cases. One mutation\u2010positive case showed an <jats:styled-content style=\"fixed-case\">AGCT<\/jats:styled-content> nodule abutting a mucinous borderline tumour, interpreted as a collision tumour. The other positive case had an <jats:styled-content style=\"fixed-case\">AGCT<\/jats:styled-content> component within the septa of a mucinous carcinoma, and both components are likely to be neoplastic. In the three cases without <jats:italic><jats:styled-content style=\"fixed-case\">FOXL<\/jats:styled-content>2<\/jats:italic> mutation, the stromal component most likely represents a non\u2010neoplastic <jats:styled-content style=\"fixed-case\">AGCT<\/jats:styled-content>\u2010like proliferation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Areas typical of <jats:styled-content style=\"fixed-case\">AGCT<\/jats:styled-content> are rarely associated with epithelial ovarian lesions. These are heterogeneous and likely to be truly neoplastic in only a subset of cases. <jats:italic><jats:styled-content style=\"fixed-case\">FOXL<\/jats:styled-content>2<\/jats:italic> mutation testing may be useful in confirming a true neoplastic <jats:styled-content style=\"fixed-case\">AGCT<\/jats:styled-content> component.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12314","type":"journal-article","created":{"date-parts":[[2013,10,19]],"date-time":"2013-10-19T14:52:42Z","timestamp":1382194362000},"page":"626-632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Adult granulosa cell tumour\u2010like areas occurring in ovarian epithelial neoplasms: report of a case series with investigation of <i><scp>FOXL<\/scp>2<\/i> mutation status"],"prefix":"10.1111","volume":"64","author":[{"given":"Naveena","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pathology Barts Health NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Blake","family":"Gilks","sequence":"additional","affiliation":[{"name":"Department of Pathology Vancouver General Hospital University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G","family":"Huntsman","sequence":"additional","affiliation":[{"name":"Department of Pathology Centre for Translational and Applied Genomics Vancouver General Hospital University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Histopathology Royal Hallamshire Hospital Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Coutts","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology Maidstone and Tunbridge Wells NHS Trust Kent 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