{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:43:37Z","timestamp":1789771417898,"version":"4.0.1"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Ampullary cancer is a relatively uncommon tumour, with a better prognosis than pancreatic cancer. The purpose of this study was to review the recent literature on ampullary adenocarcinoma, focusing on histological types and prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Using PubMed, we carried out a comprehensive search of the literature, which was extended to April 2013 to retrieve all additional publications. Ampullary cancer comprises two main histological subtypes, the pancreatobiliary type and the intestinal type. These subtypes have different pathogenetic and clinical characteristics. Clinical and histological parameters as well as immunohistochemical markers have been identified as significant prognostic factors in ampullary cancer. Moreover, several immunohistochemical markers have been studied, not only as prognostic factors but as a means of differentiating ampullary from other peri\u2010ampullary tumours, and of identifying the exact histological subtype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The considerable differences in the frequencies of the two subtypes of ampullary tumours reported in literature reinforce the necessity to define molecular markers to distinguish them. Until then, the significance of the histological subtype as a prognostic factor should be evaluated cautiously. Future research on the pathogenesis of ampullary cancer will possibly suggest that we should stop treating this type of cancer as a separate entity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12324","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T17:43:26Z","timestamp":1384191806000},"page":"759-768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Ampullary cancer \u2013 a separate clinical entity?"],"prefix":"10.1111","volume":"64","author":[{"given":"Iraklis","family":"Perysinakis","sequence":"first","affiliation":[{"name":"Third Department of Surgery \u2018George Gennimatas\u2019 General Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Margaris","sequence":"additional","affiliation":[{"name":"Third Department of Surgery \u2018George Gennimatas\u2019 General Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Kouraklis","sequence":"additional","affiliation":[{"name":"Second Department of Propaedeutic Surgery Laiko Hospital Athens University Medical School Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000149708.12335.6a"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.018887"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21374"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-006-0109-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e3283378eb0"},{"key":"e_1_2_8_7_1","volume-title":"TNM classification of malignant tumours","author":"Sobin LH","year":"2010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.9.941"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200209000-00012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.03.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.07.512"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-003-0088-5"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-004-0898-3"},{"key":"e_1_2_8_14_1","first-page":"17","article-title":"Expression of p16 protein and cyclin D1 in periampullary carcinomas","volume":"27","author":"Tuncer E","year":"2011","journal-title":"Turk Patoloji Derg."},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1177\/000313480907500904","article-title":"Important prognostic factors in adenocarcinoma of the ampulla of Vater","volume":"75","author":"Lowe MC","year":"2009","journal-title":"Am. 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