{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:19:55Z","timestamp":1780078795223,"version":"3.54.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T00:00:00Z","timestamp":1389312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Diffuse neurofibromatosis\/ganglioneuromatosis, solitary\/plexiform neurofibroma, periampullary carcinoids and gastrointestinal stromal tumour (<jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>) are the main gastrointestinal manifestations of neurofibromatosis type 1 (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u20101, von Recklinghausen disease). Inflammatory (juvenile\u2010like) polyps have not been recognised to date as specific gastrointestinal (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) manifestations of<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u20101.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We describe four males aged 23\u201365\u00a0years with<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u20101 and inflammatory (juvenile\u2010like) gastrointestinal polyps, and review the literature for similar cases. Two patients had single polyps (sigmoid colon and antrum, respectively), one had two polyps (left colon), and one had three polyps (distal oesophagus and colon). Histological appearances were variable, ranging from juvenile\u2010like to granulation tissue\u2010rich, predominantly inflammatory and hyperplastic. Three lesions showed obliterative vasculopathic changes. None had neurofibromatous or ganglioneuromatous polyps. A review of the literature disclosed 11 similar cases. Most patients presented with severe gastrointestinal symptoms and\/or anaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u20101\u2010associated inflammatory polyps probably represent specific<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>manifestations of this disorder, and should be considered, particularly in patients with<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>symptoms. They should be distinguished from inflammatory fibroid polyps and from juvenile\u2010like changes associated with ganglioneuroma\/ganglioneuromatosis and neurofibroma\/neurofibromatosis. Their aetiology remains obscure, but different mechanisms, including<jats:italic><jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u20101<\/jats:italic>inactivation,<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u20101\u2010associated vasculopathy, and localised mucosal prolapse\/damage caused by motility disorders, might be involved.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12325","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T11:33:34Z","timestamp":1384342414000},"page":"777-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Juvenile\u2010like (inflammatory\/hyperplastic) mucosal polyps of the gastrointestinal tract in neurofibromatosis type 1"],"prefix":"10.1111","volume":"64","author":[{"given":"Abbas","family":"Agaimy","sequence":"first","affiliation":[{"name":"Institute of Pathology University Hospital Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga\u2010Marie","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston MA USA"},{"name":"Institute of Pathology University Medical Centre G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopoldina","family":"Kotzina","sequence":"additional","affiliation":[{"name":"Pathology Laboratory Klinikum B\u00f6blingen\u2010Sindelfingen Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Knolle","sequence":"additional","affiliation":[{"name":"Institute of Pathology Klinikum Dessau Dessau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irith","family":"Baumann","sequence":"additional","affiliation":[{"name":"Pathology Laboratory Klinikum B\u00f6blingen\u2010Sindelfingen Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Str\u00f6bel","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Centre G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Vieth","sequence":"additional","affiliation":[{"name":"Institute of Pathology Klinikum Bayreuth Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70075-3"},{"key":"e_1_2_7_3_1","first-page":"172","article-title":"National institutes of Health Consensus Development Conference Statement: neurofibromatosis. 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