{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:19:51Z","timestamp":1773231591719,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T00:00:00Z","timestamp":1389312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Studies have indicated that the t(14;18)(q32;q21)\/<jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content><\/jats:italic>\u2013<jats:italic><jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>1<\/jats:italic> translocation is present in extranodal marginal zone lymphomas of mucosa\u2010associated lymphoid tissue (<jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma). However, only a few studies have investigated the incidence of t(14;18)\/<jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content><\/jats:italic>\u2013<jats:italic><jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>1<\/jats:italic> in primary gastrointestinal <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphomas or in diffuse large <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell lymphomas (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>). The overall significance of t(14;18)\/<jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content><\/jats:italic>\u2013<jats:italic><jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>1<\/jats:italic> in gastrointestinal <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphomas is not clear. We examined 41 gastrointestinal <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma and 23 <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> cases, with the aim of further understanding the role of t(14;18)\/<jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content><\/jats:italic>\u2013<jats:italic><jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>1<\/jats:italic> in these diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Fluorescence <jats:italic>in\u2010situ<\/jats:italic> hybridization (<jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>) assays for the detection of t(14;18)\/<jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content><\/jats:italic>\u2013<jats:italic><jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>1<\/jats:italic> and t(11;18)(q21;q21)\/<jats:italic><jats:styled-content style=\"fixed-case\">API<\/jats:styled-content>2<\/jats:italic>\u2013<jats:italic><jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>1<\/jats:italic>, along with immunostaining and histological evaluations, were performed on selected cases. Of the 64 analysed cases, one gastric <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma and one colonic <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma were positive for t(14;18)\/<jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content><\/jats:italic>\u2013<jats:italic><jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>1<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We describe what are, to our knowledge, the first reported primary colonic <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma carrying t(14;18)(q32;q21)\/<jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content><\/jats:italic>\u2013<jats:italic><jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>1<\/jats:italic>, and one of the few reported cases of gastric <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma with this translocation. As this translocation is seen in only a few gastrointestinal <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphomas, it is not useful as a diagnostic marker for routine clinical services. Although these findings suggest that t(14;18)\/<jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content><\/jats:italic>\u2013<jats:italic><jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>1<\/jats:italic> is a rare molecular event in gastrointestinal <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphomas and <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>s, further studies to elucidate the role of this genetic alteration in these diseases are indicated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12327","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T17:14:41Z","timestamp":1384535681000},"page":"791-798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The t(14;18)(q32;q21)\/<i><scp>IGH<\/scp><\/i>\u2013<i><scp>MALT<\/scp>1<\/i> translocation in gastrointestinal extranodal marginal zone lymphoma of mucosa\u2010associated lymphoid tissue (<scp>MALT<\/scp> lymphoma)"],"prefix":"10.1111","volume":"64","author":[{"given":"Shimin","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Molecular Pathology The Joint Pathology Centre Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minqi","family":"Wei","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology The Joint Pathology Centre Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Liang","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology The Joint Pathology Centre Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisy","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology The Joint Pathology Centre Bethesda MD 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