{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:00:59Z","timestamp":1780491659693,"version":"3.54.1"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>In females, columnar cell lesions (<jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>s) have been recognized as putative precursor lesions of low\u2010grade breast cancer, but their role in male breast carcinogenesis is as yet unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We reviewed surgical resections from males with breast cancer (<jats:italic>n\u00a0<\/jats:italic>=\u00a089), gynaecomastia (<jats:italic>n\u00a0<\/jats:italic>=\u00a020) and normal breast specimens from autopsies (<jats:italic>n\u00a0<\/jats:italic>=\u00a05) for the presence of <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>. In addition, we performed immunohistochemistry for cytokeratin 5\/6 (<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>5\/6), <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>14 and oestrogen receptor alpha (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>). In 19 of 89 resections (two <jats:styled-content style=\"fixed-case\">DCIS<\/jats:styled-content> cases and 17 invasive carcinoma), some individual ducts were found to contain cells with snouts on the luminal border but lacking further typical columnar cell lesion features. We mainly found three\u2010layered ductal epithelium, characteristic for gynaecomastia and confirmed by immunohistochemistry. Moreover, we found a few ducts in male breast cancer sections that were clonally negative for basal cytokeratins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found no lesions with convincing <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content> morphology at the periphery of invasive male breast cancers, in gynaecomastia or in normal male breast specimens. Although we cannot completely exclude the existence of <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>s in the male breast, these lesions seem to be very uncommon and are therefore unlikely to play a major role in male breast carcinogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12333","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T10:24:25Z","timestamp":1385375065000},"page":"818-825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Do columnar cell lesions exist in the male breast?"],"prefix":"10.1111","volume":"64","author":[{"given":"Anoek H J","family":"Verschuur\u2010Maes","sequence":"first","affiliation":[{"name":"Departments of Pathology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kornegoor","sequence":"additional","affiliation":[{"name":"Departments of Pathology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C","family":"de Bruin","sequence":"additional","affiliation":[{"name":"St Antonius Ziekenhuis Nieuwegein Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost J","family":"Oudejans","sequence":"additional","affiliation":[{"name":"Diakonessenhuis Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J","family":"van Diest","sequence":"additional","affiliation":[{"name":"Departments of Pathology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910530403"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68226-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200001000-00009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.174"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110025"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-1015-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2348"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2258"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318161d1a5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181adfdcf"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199903)187:4<383::AID-PATH299>3.0.CO;2-H"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200305000-00001"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.02.009"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318233523f"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-012-1279-y"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12039"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2013.01.011"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2591-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1839-x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200176"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03786.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.5265"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-012-1312-1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2013.08.008"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.73"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.8.2263"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23873"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-007-0408-5"},{"key":"e_1_2_7_30_1","first-page":"223","article-title":"Long\u2010term follow\u2010up of in situ carcinoma of the breast","volume":"11","author":"Eusebi V","year":"1994","journal-title":"Semin. 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