{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T23:17:42Z","timestamp":1774480662798,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T00:00:00Z","timestamp":1391558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To report on the clinicopathological features of 20 cases of microcystic urothelial bladder carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The extent of microcystic component varied from 50\u2013100% of the specimens. The cysts were round\u2013oval and of varying sizes; the periphery of large cysts was frequently punctuated by many smaller cysts. The cysts were lined by urothelial, low columnar cells or by a single layer of flattened epithelium of low\u2013intermediate nuclear grade. Focal high\u2010grade conventional urothelial carcinoma was present in eight cases. Immunohistochemistry demonstrated variable positivity for cytokeratins 7 and 20, <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>5<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>, p63 and <jats:styled-content style=\"fixed-case\">GATA<\/jats:styled-content>3. Extent of expression of <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i67, p53 and p27<jats:sup>kip1<\/jats:sup> ranged from 20\u201360%, 10\u201340% and 10\u201330% of cells, respectively. On follow\u2010up, 11 patients died of disease at 11\u201356\u00a0months and three patients were alive with disease at 26\u201337\u00a0months. Univariate survival analysis showed no differences for microcystic carcinoma versus conventional urothelial carcinoma (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.548).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Microcystic urothelial carcinoma may pose diagnostic difficulties, especially in limited biopsy samples, where it may be mistaken for cystitis glandularis or adenocarcinoma of the bladder. Histological features, clinical history and appropriate immunohistochemical studies should help to distinguish it from its mimics. Aggressiveness seems to be related to higher stage at diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12345","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T13:38:40Z","timestamp":1386596320000},"page":"872-879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Microcystic urothelial carcinoma: morphology, immunohistochemistry and clinical behaviour"],"prefix":"10.1111","volume":"64","author":[{"given":"Antonio","family":"Lopez Beltran","sequence":"first","affiliation":[{"name":"Unit of Anatomic Pathology Department of Surgery Faculty of Medicine University of Cordoba Cordoba Spain"},{"name":"Funda\u00e7\u00e3o Champalimaud Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"Montironi","sequence":"additional","affiliation":[{"name":"Section of Pathological Anatomy Polytechnic University of the Marche Region School of Medicine Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"93","volume-title":"World Health Organization classification of tumours: pathology and genetics of tumours of the urinary system and male genital organs","author":"Lopez\u2010Beltran A","year":"2004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.05.009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07271.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/96.5.635"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03167.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2008.12.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-008-0693-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-3-36"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02893496"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-004-7968-y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1997.00123.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.11.001"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800559"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4081\/rt.2011.e22"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.5858\/2002-126-0859-MTCC","article-title":"Microcystic transitional cell carcinoma: a report of 2 cases arising in the renal pelvis","volume":"126","author":"Leroy X","year":"2002","journal-title":"Arch. 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