{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T09:52:25Z","timestamp":1769939545160,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T00:00:00Z","timestamp":1393286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Pleomorphic lobular carcinoma <jats:italic>in\u00a0situ<\/jats:italic> (<jats:styled-content style=\"fixed-case\">PLCIS<\/jats:styled-content>) of the breast is a distinctive entity, but its behaviour and management are unclear. The purpose of this study was to review a relatively large number of cases and to evaluate the risk of recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Cases of <jats:styled-content style=\"fixed-case\">PLCIS<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a047) from a 12\u2010year period were reviewed. The clinical, radiological and pathological findings were recorded. Immunohistochemistry for oestrogen receptor (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>), progesterone receptor (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">HER<\/jats:styled-content>2 was performed. Thirty\u2010one patients had no concurrent breast cancer or past history of breast cancer, and six (19.4%) of these had local recurrence; all tumours (four invasive carcinoma and two <jats:styled-content style=\"fixed-case\">PLCIS<\/jats:styled-content>) were ipsilateral. Younger age at presentation was a risk factor for local recurrence: patients with recurrence had a mean age (range) of 52.5\u00a0years (44\u201359\u00a0years), versus 60.6\u00a0years (40\u201381\u00a0years) for those without (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). Three of 31 patients were treated with radiation therapy (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>), and none of these developed local recurrence. <jats:styled-content style=\"fixed-case\">PLCIS<\/jats:styled-content> had an adverse <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HER<\/jats:styled-content>2 molecular profile, with at least 41.2% of the cases overexpressing <jats:styled-content style=\"fixed-case\">HER<\/jats:styled-content>2. Moreover, at least 11.7% of the cases were triple\u2010negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study included the largest number of patients who had no concurrent breast cancer or past history of breast cancer with the longest clinical follow\u2010up, providing insights into management practices for <jats:styled-content style=\"fixed-case\">PLCIS<\/jats:styled-content> and the risk of recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12353","type":"journal-article","created":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T14:38:36Z","timestamp":1388155116000},"page":"981-993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Pleomorphic lobular carcinoma <i>in\u00a0situ<\/i> of the breast: clinicopathological review of 47 cases"],"prefix":"10.1111","volume":"64","author":[{"given":"Thaer","family":"Khoury","sequence":"first","affiliation":[{"name":"Department of Pathology Roswell Park Cancer Institute Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rouzan G","family":"Karabakhtsian","sequence":"additional","affiliation":[{"name":"Department of Pathology Montefiore Medical Center Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mattson","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine Roswell Park Cancer Institute Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Roswell Park Cancer Institute Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Syriac","sequence":"additional","affiliation":[{"name":"Department of Pathology Roswell Park Cancer Institute Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Pathology Roswell Park Cancer Institute Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Roswell Park Cancer Institute Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1830-6222","authenticated-orcid":false,"given":"Mohamed M","family":"Desouki","sequence":"additional","affiliation":[{"name":"Department of Pathology Vanderbilt University Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"78","volume-title":"World Health Organization classification of tumors of the breast","author":"Lakhani SR","year":"2012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-008-0607-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-001-0541-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000030450.20581.E3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12062"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.55418\/9781933477053-ch03","volume-title":"Tumors of the mammary gland, AFIP atlas of tumor pathology","author":"Tavassoli FA","year":"2009"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.5.1474"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.5858\/2007-131-18-ASOCCO","article-title":"Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology\/College of American Pathologists Clinical Practice Guideline Update","volume":"131","author":"Wolff AC","year":"2007","journal-title":"Arch. 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