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An <jats:styled-content style=\"fixed-case\">EORTC<\/jats:styled-content> Workshop was convened to describe in detail the features of this putative neoplasm and evaluate its nosological status with respect to other cutaneous <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> lymphomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Sixty\u2010one <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> cases were analysed at the workshop; clinical details, often with photographs, histological sections, immunohistochemical results, treatment and patient outcome were discussed and recorded. Eighteen cases had distinct features and conformed to the diagnosis of aggressive epidermotropic cutaneous <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> lymphoma. The patients typically present with widespread plaques and tumours, often ulcerated and haemorrhagic, and histologically have striking pagetoid epidermotrophism. A <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content><jats:sup>+<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45<jats:styled-content style=\"fixed-case\">RO<\/jats:styled-content><jats:sup>\u2212<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>2<jats:sup>\u2212<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5<jats:sup>\u2212<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>56<jats:sup>\u2212<\/jats:sup> phenotype, with one or more cytotoxic markers, was found in seven of 18 patients, with a very similar phenotype in the remainder. The tumours seldom involve lymph nodes, but mucosal and central nervous system involvement are not uncommon. The prognosis is poor, with a median survival of 12\u00a0months. Examples of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> mycosis fungoides, lymphomatoid papulosis and Woringer\u2013Kolopp disease presented the typical features well documented in the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> forms of those diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aggressive epidermotropic cutaneous <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> lymphoma is a distinct lymphoma that warrants inclusion as a distinct entity in future revisions of lymphoma classifications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12371","type":"journal-article","created":{"date-parts":[[2014,1,18]],"date-time":"2014-01-18T08:24:42Z","timestamp":1390033482000},"page":"425-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Aggressive epidermotropic cutaneous <scp>CD<\/scp>8<sup>+<\/sup> lymphoma: a cutaneous lymphoma with distinct clinical and pathological features. 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