{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T06:43:49Z","timestamp":1769237029698,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T00:00:00Z","timestamp":1396828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To present 18 cases of spindle cell thymoma (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> type <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) with prominent neuroendocrine morphology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The patients were nine men and nine women aged 36\u201376\u00a0years (average: 56\u00a0years). Clinically, the patients presented with non\u2010specific symptoms such as chest pain, or were entirely asymptomatic. None of the patients had a history of autoimmune syndrome. Surgical resection was performed in all patients. The tumour size ranged from 30 to 110\u00a0mm. Macroscopically, the tumours were described as light brown or tan masses with a homogeneous and solid appearance. Microscopically, all tumours showed areas that closely resembled the typical growth pattern of neuroendocrine tumours, i.e. rosette\u2010like structures or a trabecular, insular or ribbon\u2010like arrangement of tumour cells. Areas of more conventional spindle cell thymoma were present in all cases. Seven cases were encapsulated, and 10 cases were invasive tumours. Immunohistochemically, the tumours were positive for pancytokeratin but negative for synaptophysin and chromogranin <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>. Follow\u2010up information for 10 patients showed that all patients were alive after a period ranging from 1\u00a0month to 6\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Familiarity with this particular pattern of thymoma is important in order to separate this tumour from true neuroendocrine carcinoma and prevent unnecessary adjuvant treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12376","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T06:06:59Z","timestamp":1396850819000},"page":"111-118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Spindle cell thymomas with neuroendocrine morphology: a clinicopathological and immunohistochemical study of 18 cases"],"prefix":"10.1111","volume":"65","author":[{"given":"Annikka","family":"Weissferdt","sequence":"first","affiliation":[{"name":"Department of Pathology MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar A","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Pathology MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP76KEGWQKWOKA"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199908000-00014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.07.011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181f085c5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1994.tb01333.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1309\/E4JB3EBCD3R08NHG"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318208354b"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.08.025"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920101)69:1<92::AID-CNCR2820690117>3.0.CO;2-#"},{"key":"e_1_2_6_11_1","first-page":"74","volume-title":"Atlas of tumour pathology","author":"Rosai J","year":"1976"},{"key":"e_1_2_6_12_1","first-page":"82","volume-title":"Atlas of tumor pathology","author":"Shimasato Y","year":"1997"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP36ALGUZWOSEA"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1994.tb02936.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP7KBP4QQLRLXW"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1309\/3PDN-PMT5-EQTM-H0CD"},{"key":"e_1_2_6_17_1","first-page":"154","volume-title":"Pathology and genetics of tumours of the lung, pleura, thymus and heart","author":"Kuo TT","year":"2004"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01133.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-003-0961-5"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-7-520"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890415)63:8<1493::AID-CNCR2820630807>3.0.CO;2-C"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.11.1722"},{"key":"e_1_2_6_23_1","first-page":"587","article-title":"Spindle\u2010cell neuroendocrine carcinomas of the thymus (spindle\u2010cell thymic carcinoid): a clinicopathologic and immunohistochemical study of seven cases","volume":"12","author":"Moran CA","year":"1999","journal-title":"Mod. 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