{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:18:22Z","timestamp":1790360302869,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T00:00:00Z","timestamp":1395792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the National R&D Program for Cancer Control, Ministry for Health and Welfare, Republic of Korea","award":["1220220"],"award-info":[{"award-number":["1220220"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To address whether napsin\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      is useful for identifying metastatic adenocarcinomas of pulmonary origin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010four cases of adenocarcinoma that metastasized from the lungs to various sites and 1762 cases of carcinoma from various organs were immunostained for napsin\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>\n                      \u20101,\n                      <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>\n                      7,\n                      <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>\n                      20 and\n                      <jats:styled-content style=\"fixed-case\">CDX<\/jats:styled-content>\n                      2 using tissue microarray. The expression patterns of napsin\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>\n                      \u20101 in metastatic pulmonary adenocarcinomas were compared with matched primary lung tumours. Napsin\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>\n                      \u20101 were expressed in 87.0% and 81.5% of the metastatic pulmonary adenocarcinomas, respectively. Although there was no significant difference in the positivity of napsin\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>\n                      \u20101 as a single marker in metastatic pulmonary adenocarcinomas, the expression scores for napsin\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      were much higher than those for\n                      <jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>\n                      \u20101 (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.001). Moreover, the positivity and expression scores of napsin\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      in primary pulmonary adenocarcinomas were maintained in metastatic adenocarcinomas better than\n                      <jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>\n                      \u20101. Most non\u2010pulmonary adenocarcinomas were negative for napsin\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      , except for renal cell carcinomas (13.4%), ovarian adenocarcinomas (7.1%) and uterine endometrial adenocarcinomas (14.5%). In particular, clear cell adenocarcinomas of ovary (68.8%) and uterus (66.7%) frequently expressed napsin\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These data suggest that napsin\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      may be a useful marker for identifying metastatic adenocarcinomas of pulmonary origin in combination with\n                      <jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>\n                      \u20101.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.12383","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T06:14:14Z","timestamp":1391148854000},"page":"195-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Napsin\n                    <scp>A<\/scp>\n                    is a useful marker for metastatic adenocarcinomas of pulmonary origin"],"prefix":"10.1111","volume":"65","author":[{"given":"Moon\u2010Young","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pathology Seoul National University Hospital Seoul South Korea"},{"name":"Department of Pathology Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heounjeong","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Hospital Seoul South Korea"},{"name":"Department of Pathology Seoul 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