{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:59:22Z","timestamp":1778914762409,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T00:00:00Z","timestamp":1400198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Ovarian mature teratoma is a benign tumour, whereas mature teratoma in adult testicular germ cell tumours (<jats:styled-content style=\"fixed-case\">TGCT<\/jats:styled-content>s) is considered to be a malignant tumour. IMP3, an oncofetal protein, plays an important role in embryogenesis and carcinogenesis. IMP3 has been demonstrated to be a malignant biomarker that is mainly expressed in malignant neoplasms rather than benign tissues. The aim of this study was to analyse <jats:styled-content style=\"fixed-case\">IMP<\/jats:styled-content>3 expression in germ cell tumours, and compare its expression between male and female teratomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>One hundred and seventy\u2010eight cases (62 <jats:styled-content style=\"fixed-case\">TGCT<\/jats:styled-content>s, 52 ovarian teratomas, 27 metastatic testicular teratomas, and 37 cases of normal testicular tissue) obtained from the archives of two large academic medical centres were examined for <jats:styled-content style=\"fixed-case\">IMP<\/jats:styled-content>3 expression. Of the 62 <jats:styled-content style=\"fixed-case\">TGCT<\/jats:styled-content>s, 30 had mature teratoma components. IMP3 expression was present in 100% (30\/30) of testicular mature teratoma components, and in 96% (26\/27) of metastatic testicular teratomas. Other <jats:styled-content style=\"fixed-case\">TGCT<\/jats:styled-content> components also expressed <jats:styled-content style=\"fixed-case\">IMP<\/jats:styled-content>3 in 99% of cases (78\/79). IMP3 expression was negative in all female mature teratomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We describe for the first time an immunostaining marker that has differential expression in male and female mature teratomas, indicating that their pathogenesis differs. High expression of <jats:styled-content style=\"fixed-case\">IMP<\/jats:styled-content>3 in adult mature testicular teratomas supports their malignant nature.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12409","type":"journal-article","created":{"date-parts":[[2014,3,8]],"date-time":"2014-03-08T10:16:43Z","timestamp":1394273803000},"page":"483-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Differential expression of <scp>IMP<\/scp>3 between male and female mature teratomas\u2014immunohistochemical evidence of malignant nature"],"prefix":"10.1111","volume":"65","author":[{"given":"Steven","family":"Goodman","sequence":"first","affiliation":[{"name":"Department of Pathology University of Massachusetts Medical School Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Massachusetts Medical School Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Massachusetts Medical School Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.11.1777"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112989"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00609-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841868409136019"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950501)75:9<2244::AID-CNCR2820750909>3.0.CO;2-I"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66352-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200401000-00002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000087822.71739.9a"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66053-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(68)90384-0"},{"key":"e_1_2_6_12_1","first-page":"598","article-title":"Pure ovarian immature teratoma, a unique and curable disease: 10\u00a0years experience of 32 prospectively treated patients","volume":"84","author":"Bonazzi C","year":"1994","journal-title":"Obstet. 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