{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:51:59Z","timestamp":1791294719370,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T00:00:00Z","timestamp":1399852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"SK telecom health project","award":["06-2012-157\/122"],"award-info":[{"award-number":["06-2012-157\/122"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Aims<\/jats:title>In this study, we examined BRAF<\/jats:styled-content><\/jats:italic> mutation in a wide range of histiocytic and dendritic cell neoplasms and compared its detection rate in each disease group.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>A total of 129 cases of histiocytic, dendritic cell and other related lesions were reviewed from the archives of 10 hospitals in Korea. The cases consisted of histiocytic sarcoma, follicular dendritic cell (FDC<\/jats:styled-content>) sarcoma, interdigitating cell sarcoma, Langerhans cell histiocytosis (LCH<\/jats:styled-content>), Langerhans cell sarcoma, blastic plasmacytoid dendritic cell neoplasm, acute monocytic leukaemia M5, giant cell tumour, xanthogranuloma, inflammatory myofibroblastic tumour and Rosai\u2013Dorfman disease. BRAF<\/jats:styled-content><\/jats:italic> mutation analysis was performed by Sanger sequencing and PNA<\/jats:styled-content>cqPCR<\/jats:styled-content>. All the detected mutations of BRAF<\/jats:styled-content><\/jats:italic> were V600E. Histiocytic sarcoma exhibited the highest rate of BRAF<\/jats:styled-content><\/jats:italic>V600E<\/jats:italic><\/jats:sup> (62.5%, five of eight), followed by Langerhans cell tumours (25%, seven of 28), FDC<\/jats:styled-content> sarcoma (18.5%, five of 27) and giant cell tumour (6.7%, two of 30). The other tumours did not harbour BRAF<\/jats:styled-content><\/jats:italic> mutations. In histiocytic sarcoma, FDC<\/jats:styled-content> sarcoma and LCH<\/jats:styled-content>, there were no significant differences in clinical features between tumours containing BRAF<\/jats:styled-content><\/jats:italic>V600E<\/jats:italic><\/jats:sup> and those with BRAF<\/jats:styled-content><\/jats:italic>wt<\/jats:italic><\/jats:sup>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>BRAF<\/jats:styled-content><\/jats:italic>V600E<\/jats:italic><\/jats:sup> was not limited to LCH<\/jats:styled-content> and was detected more frequently in histiocytic sarcoma. Our findings suggest that the BRAF<\/jats:styled-content><\/jats:italic> pathway may contribute to the pathogenesis or malignant transformation of histiocytic and dendritic cell neoplasms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12416","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T21:21:03Z","timestamp":1397164863000},"page":"261-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":216,"title":["Frequent detection of BRAF<\/i>V<\/sup><\/scp>600E<\/sup> mutations in histiocytic and dendritic cell neoplasms"],"prefix":"10.1111","volume":"65","author":[{"given":"Heounjeong","family":"Go","sequence":"first","affiliation":[{"name":"Department of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Kyung","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Pathology Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jooryung","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology Inha University Hospital Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo\u2010Duk","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology Chonnam National University Medical School Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jeong","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Ulsan College of Medicine Ulsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Inje University Sanggye Paik Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeongsin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology Catholic University Seoul St. Mary Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sookee","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Pathology Hallym University Sacred Heart Hospital Anyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Pathology Seoul National University Boramae Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210704"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014209"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121343109"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-368209"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-279083"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-430140"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-429597"},{"key":"e_1_2_7_9_1","volume-title":"Who classification of tumors of haematopoietic and lymphoid tissue","author":"Swerdlow S","year":"2008"},{"key":"e_1_2_7_10_1","volume-title":"World health organization classification of tumours: pathology and genetics of tumours of the skin","author":"LeBoit P","year":"2006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32834db53e"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08915.x"},{"key":"e_1_2_7_13_1","volume-title":"Hematopathology","author":"Jaffe E","year":"2011"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1383-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132557"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/S0046-8177(03)00413-1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-1917"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2012-201194"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2494-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01418.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950220309"},{"key":"e_1_2_7_22_1","first-page":"421","article-title":"Hematophagic histiocytosis: a clinicopathologic analysis of 23 cases with special reference to the association with peripheral T\u2010cell lymphoma","volume":"93","author":"Chang CS","year":"1994","journal-title":"J. Formos. Med. Assoc."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199709)29:3<157::AID-MPO1>3.0.CO;2-C"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000131541.95394.23"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-446286"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12057"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12416","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.12416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:29:17Z","timestamp":1696332557000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.12416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,12]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/his.12416"],"URL":"https:\/\/doi.org\/10.1111\/his.12416","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,12]]},"assertion":[{"value":"2014-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}