{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:19:47Z","timestamp":1790173187638,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T00:00:00Z","timestamp":1400198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Hepatic iron deposition unrelated to hereditary haemochromatosis is common in cirrhosis. The aim of this study was to determine whether hepatic haemosiderosis secondary to cirrhosis is associated with iron deposition in extrahepatic organs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Records of consecutive adult patients with cirrhosis who underwent autopsy were reviewed. Storage iron was assessed by histochemical staining of sections of liver, heart, pancreas and spleen. <jats:italic><jats:styled-content style=\"fixed-case\">HFE<\/jats:styled-content><\/jats:italic> genotyping was performed on subjects with significant liver, cardiac and\/or pancreatic iron. The 104 individuals were predominantly male (63%), with a mean age of 55\u00a0years. About half (46%) had stainable hepatocyte iron, 2+ or less in most cases. In six subjects, there was heavy iron deposition (4+) in hepatocytes and biliary epithelium. All six of these cases had pancreatic iron and five also had cardiac iron. None of these subjects had an explanatory <jats:italic><jats:styled-content style=\"fixed-case\">HFE<\/jats:styled-content><\/jats:italic> genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this series, heavy hepatocyte iron deposition secondary to cirrhosis was commonly associated with pancreatic and cardiac iron. Although this phenomenon appears to be relatively uncommon, the resulting pattern of iron deposition is similar to haemochromatosis. Patients with marked hepatic haemosiderosis secondary to cirrhosis may be at risk of developing extrahepatic complications of iron overload.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12417","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T08:26:58Z","timestamp":1395044818000},"page":"561-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Iron overload secondary to cirrhosis: a mimic of hereditary haemochromatosis?"],"prefix":"10.1111","volume":"65","author":[{"given":"Murad","family":"Abu Rajab","sequence":"first","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology University of Iowa Roy J. and Lucille A. Carver College of Medicine Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leana","family":"Guerin","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Iowa Roy J. and Lucille A. Carver College of Medicine Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Molecular and Experimental Medicine The Scripps Research Institute La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle E","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology University of Iowa Roy J. and Lucille A. Carver College of Medicine Iowa City IA USA"},{"name":"Program in Free Radical and Radiation Biology University of Iowa Roy J. and Lucille A. Carver College of Medicine Iowa City IA USA"},{"name":"Iowa City Veterans Administration Medical Center Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.013"},{"key":"e_1_2_6_3_1","first-page":"74","article-title":"Hepatic hemosiderin deposits. Incidence in 558 biopsies from patients with and without intrinsic hepatic disease","volume":"107","author":"Zimmerman HJ","year":"1960","journal-title":"Arch. Intern. Med."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1960.00270170024004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9041250"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80011-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500050109"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4844"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-258467"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4855"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.06.027"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.07.006"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2005.01004.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31819f2280"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(95)06212-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/10906570050114830"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225615"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.06.025"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1986.174"},{"key":"e_1_2_6_20_1","first-page":"103","article-title":"Hemolytic syndromes and red cell membrane abnormalities in liver disease","volume":"17","author":"Cooper RA","year":"1980","journal-title":"Semin. Hematol."},{"key":"e_1_2_6_21_1","first-page":"69","article-title":"Mechanisms of hemolysis in liver disease","volume":"20","author":"Morse EE","year":"1990","journal-title":"Ann. Clin. Lab. Sci."}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12417","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.12417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T01:28:56Z","timestamp":1696296536000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.12417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,16]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/his.12417"],"URL":"https:\/\/doi.org\/10.1111\/his.12417","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,16]]},"assertion":[{"value":"2013-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}