{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:08:03Z","timestamp":1790744883253,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T00:00:00Z","timestamp":1402012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The more differentiated fetal component of hepatoblastoma (<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>) is characterized by increased expression of tight junction (<jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content>) proteins claudin\u20101 and \u20102 when compared with embryonal component. Expression patterns of the recently identified <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content> protein tricellulin and the epigenetic regulator enzyme <jats:styled-content style=\"fixed-case\">EZH<\/jats:styled-content>2 were investigated in epithelial subtypes of <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content> and related to survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Twenty\u2010one cases of epithelial <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>s subtyped as pure fetal (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>12) and embryonal\/fetal (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>9), along with 16 non\u2010tumorous samples from surrounding liver, were analysed by immunohistochemistry for tricellulin, \u03b2\u2010catenin and <jats:styled-content style=\"fixed-case\">EZH<\/jats:styled-content>2 expression. No significant differences were revealed in overall survival between fetal and embryonal\/fetal types of <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>s. The fetal component, however, showed considerably increased tricellulin expression while the embryonal component displayed significantly increased nuclear <jats:styled-content style=\"fixed-case\">EZH<\/jats:styled-content>2 positivity, in comparison to other epithelial subtypes and non\u2010tumorous surrounding hepatocytes. Strong nuclear \u03b2\u2010catenin staining was notably more frequent in embryonal than in fetal types. High tricellulin expression was associated with significantly increased overall survival (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.03), while elevated <jats:styled-content style=\"fixed-case\">EZH<\/jats:styled-content>2 expression was linked to the presence of distant metastases (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data indicate that patients with treated <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>s showing high expression of tricellulin have significantly better overall survival, independent of histological subtype. Increased nuclear expression of <jats:styled-content style=\"fixed-case\">EZH<\/jats:styled-content>2 was associated with the presence of distant metastases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12436","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T07:38:45Z","timestamp":1397633925000},"page":"631-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["High tricellulin expression is associated with better survival in human hepatoblastoma"],"prefix":"10.1111","volume":"65","author":[{"given":"Krisztina","family":"Schlachter","sequence":"first","affiliation":[{"name":"Second Department of Pathology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nika","family":"Gyugos","sequence":"additional","affiliation":[{"name":"Second Department of Pathology Semmelweis University Budapest 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