{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:06:35Z","timestamp":1765609595811},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Aims<\/jats:title>The handling and examination of sentinel lymph nodes (SLN<\/jats:styled-content>s) to detect metastasis is critical in the assessment of early breast cancer patients. This survey investigates the variation in practise followed by pathology units across the United Kingdom in the staging evaluation of axillary lymph nodes (ALN<\/jats:styled-content>s).<\/jats:p><\/jats:sec>Methods and results<\/jats:title>A structured questionnaire, approved by the National Health Service Breast Screening Programme pathology Big 18 committee, was circulated among all pathologists. There were 160 respondents; 92% performed SLN<\/jats:styled-content> biopsy for staging, 97% had a protocol for processing SLN<\/jats:styled-content>s and most laboratories examined the ALN<\/jats:styled-content>s using formalin\u2010fixed, paraffin\u2010embedded (FFPE<\/jats:styled-content>) samples (85.6%). A few used PCR<\/jats:styled-content> (7.5%), frozen section (3.8%) or touch imprint cytology (3.1%), with or without subsequent FFPE<\/jats:styled-content> section examination. Currently, 33% perform serial sectioning, with the majority of the rest (75%) staining three levels using H&E. Most units (85%) undertook immunohistochemistry evaluation only when suspicious cells were detected on H&E\u2010stained sections.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The range of practise in UK<\/jats:styled-content> histopathology departments is described with regard to the dissection and evaluation of ALN<\/jats:styled-content>s\/SLN<\/jats:styled-content> biopsy. The variation in practise was not very marked and most departments adhered to national guidelines. Any UK<\/jats:styled-content> study seeking to relate ALN<\/jats:styled-content> status and outcome would need to be mindful of the variability in nodal processing and examination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12440","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T02:02:41Z","timestamp":1398132161000},"page":"707-711","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pathological evaluation of the staging axillary lymph nodes for breast cancer: a national survey in the United Kingdom"],"prefix":"10.1111","volume":"65","author":[{"given":"Rashmi","family":"Verma","sequence":"first","affiliation":[{"name":"Leeds Teaching Hospitals NHS Trust Department of Breast Surgery St James University Hospital Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sreekumar","family":"Sundara Rajan","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cancer and Pathology University of Leeds St James University Hospital Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldo T","family":"Verghese","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cancer and Pathology University of Leeds St James University Hospital Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieran","family":"Horgan","sequence":"additional","affiliation":[{"name":"Leeds Teaching Hospitals NHS Trust Department of Breast Surgery St James University Hospital Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M","family":"Hanby","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cancer and Pathology University of Leeds St James University Hospital Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Lane","sequence":"additional","affiliation":[{"name":"Leeds Teaching Hospitals NHS Trust Department of Breast Surgery St James University Hospital Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199409000-00015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)11104-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2008.10.036"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2009.01.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.7554"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.90"},{"key":"e_1_2_7_8_1","volume-title":"Pathology reporting of breast disease","author":"Ellis IO","year":"2005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503143121101"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198107023050102"},{"key":"e_1_2_7_11_1","unstructured":"National Institute for Health and Care Excellence (NICE).Intraoperative tests (RD\u2010100i OSNA system and Metasin test) for detecting sentinel lymph node metastases in breast cancer. NICE diagnostic guidance 8 2013 ISBN 978\u20101\u20104731\u20100263\u20107 Manchester."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9386"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12440","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.12440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:18:47Z","timestamp":1696313927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.12440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,5]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/his.12440"],"URL":"https:\/\/doi.org\/10.1111\/his.12440","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,5]]},"assertion":[{"value":"2013-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}