{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:38:20Z","timestamp":1790527100838,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T00:00:00Z","timestamp":1421971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>In this review, we highlight adaptations in the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> 2012 classification of papillary and neuroendocrine breast lesions as compared with the previous 2003 version. Consensus criteria for distinguishing atypical ductal hyperplasia from ductal carcinoma <jats:italic>in situ<\/jats:italic> within an intraductal papilloma are proposed. The absence of myoepithelial cells around the wall of an encapsulated papillary carcinoma, although raising consideration of an indolent tumour with minimal invasion, is currently regarded as <jats:italic>in\u2010situ<\/jats:italic> disease for staging purposes. The majority of solid papillary carcinomas are classified as <jats:italic>in\u2010situ<\/jats:italic> tumours, but lesions with irregular tumour islands within desmoplastic stroma may be considered to be invasive. The diagnosis of solid papillary carcinoma without further qualification as either <jats:italic>in\u2010situ<\/jats:italic> or invasive disease is discouraged. When invasive papillary carcinoma is seen in the breast, metastatic papillary carcinoma from other organ sites needs to be excluded. <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> 2012 classifies neuroendocrine breast tumours as well\u2010differentiated neuroendocrine tumour, small\u2010cell carcinoma, and invasive breast carcinoma with neuroendocrine differentiation. There is currently no clinical impact of identifying neuroendocrine differentiation in conventional invasive breast carcinomas, apart from acknowledging its frequent occurrence in subtypes such as the hypercellular variant of mucinous carcinoma and solid papillary carcinoma.<\/jats:p>","DOI":"10.1111\/his.12463","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T06:44:47Z","timestamp":1400654687000},"page":"761-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Papillary and neuroendocrine breast lesions: the <scp>WHO<\/scp> stance"],"prefix":"10.1111","volume":"66","author":[{"given":"Puay Hoon","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Pathology Singapore General Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J","family":"Schnitt","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc J","family":"van de Vijver","sequence":"additional","affiliation":[{"name":"Department of Pathology Academic Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian O","family":"Ellis","sequence":"additional","affiliation":[{"name":"University of Nottingham Nottingham City Hospital NHS Trust Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil R","family":"Lakhani","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Pathology Queensland University of Queensland Brisbane Qld Australia"},{"name":"Department of Molecular and Cellular Pathology School of Medicine University of Queensland Brisbane Qld Australia"},{"name":"University of Queensland Centre for Clinical Research The Royal Brisbane &amp; Women's Hospital Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,23]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"World Health Organization classification of tumours of the breast","author":"Lakhani SR","year":"2012"},{"key":"e_1_2_6_3_1","volume-title":"Pathology & genetics. 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