{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:23:05Z","timestamp":1751383385816},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T00:00:00Z","timestamp":1417996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Self\u2010expanding metallic stents (<jats:styled-content style=\"fixed-case\">SEMS<\/jats:styled-content>) are increasingly being used in obstructing colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>) as a \u2018bridge to surgery\u2019, allowing conversion of potentially high\u2010risk emergency resections to elective procedures. Stenting may cause a wide array of histological changes. We present the largest series to date of stented <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>, performed and reported at a single institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Stented CRC specimens received in January 2006 to December 2011 were identified from our pathology database. Slides for each case were independently reviewed by two pathologists, and a consensus was reached. A total of 72 CRCs were identified, 15 at or proximal to the splenic flexure, and 57 left\u2010sided. Thirty\u2010six were stage p<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>3 and 36 were stage p<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>4. Perforation was observed in 14 cases. The effects of stenting on the tumour included tumour necrosis (100%) and flat ulceration (77.8%). The spectrum of changes in the background bowel included mimics of inflammatory bowel disease, tumour regression post\u2010neoadjuvant therapy, and ischaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Given the inclusion of stenting of <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> as a bridge to surgery in the current <jats:styled-content style=\"fixed-case\">NICE<\/jats:styled-content> guidelines, we expect to see increasing numbers of such cases. In our study, a range of changes were encountered that mimic other bowel diseases, from simple fissuring to chronic inflammatory bowel disease and neoadjuvant regression change.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12467","type":"journal-article","created":{"date-parts":[[2014,5,30]],"date-time":"2014-05-30T07:17:11Z","timestamp":1401434231000},"page":"480-484","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Spectrum of histopathological changes encountered in stented colorectal carcinomas"],"prefix":"10.1111","volume":"66","author":[{"given":"Eve","family":"Fryer","sequence":"first","affiliation":[{"name":"Department of Cellular Pathology John Radcliffe Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim J","family":"Gorissen","sequence":"additional","affiliation":[{"name":"Department of Surgery John Radcliffe Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai Mun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology John Radcliffe Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Guy","sequence":"additional","affiliation":[{"name":"Department of Surgery John Radcliffe Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runjan","family":"Chetty","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology John Radcliffe Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,8]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Cancer Research UK Real\u2010time National database. Available at:http:\/\/www.cancerresearchuk.org\/cancer-info\/cancerstats\/types\/bowel\/incidence\/uk-bowel-cancer-incidence-statistics(accessed 15 January 2014)."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2008.01613.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0748-7983(95)95563-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2012.10.003"},{"key":"e_1_2_8_6_1","unstructured":"National Institute for Health and Clinical Excellence (NICE).Colorectal cancer: the diagnosis and management of colorectal cancer. NICE Clinical Guideline 131; 2011. 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